Journal ArticleDOI
Finite element analysis of a personalized femoral scaffold with designed microarchitecture.
Ponnusamy Pandithevan,G. Saravana Kumar +1 more
- Vol. 224, Iss: 7, pp 877-889
TLDR
The comparison of results with simulation of healthy femur shows an overall correspondence in stress and strain state which will provide optimized mechanical properties for avoiding stress shielding, and adequate strength to avoid failure risk and for active bone tissue regeneration.Abstract:
Tissue engineering scaffolds with intricate and controlled internal structure can be realized using computer-aided design (CAD) and layer manufacturing (LM) techniques. Design and manufacturing of scaffolds for load-bearing bone sites should consider appropriate biocompatibile materials with interconnected porosity, surface properties, and sufficient mechanical properties that match the surrounding bone, in order to provide adequate support, and to mimic the physiological stress—strain state so as to stimulate new tissue growth. The authors have previously published methods for estimating subject- and site-specific bone modulus using computed tomography (CT) data, CAD, and process planning for LM of controlled porous scaffolds. This study evaluates the mechanical performance of the designed porous hydroxyapite scaffolds in load-bearing sites using a finite element (FE) approach. A subject-specific FE analysis using femoral, defect site geometry and anisotropic material assignment based on CT data ...read more
Citations
More filters
Journal ArticleDOI
Load-Adaptive Scaffold Architecturing: A Bioinspired Approach to the Design of Porous Additively Manufactured Scaffolds with Optimized Mechanical Properties
Alberto Rainer,Sara Maria Giannitelli,Dino Accoto,Stefano De Porcellinis,Eugenio Guglielmelli,Marcella Trombetta +5 more
TL;DR: The present study envisages an innovative strategy for the fabrication of highly optimized structures, based on the a priori finite element analysis (FEA) of the physiological load set at the implant site, using a simple and intuitive geometry as a proof ofprinciple application.
Journal ArticleDOI
Optimization of the configuration of porous bone scaffolds made of Polyamide/Hydroxyapatite composites using Selective Laser Sintering for tissue engineering applications
TL;DR: Based on the results of finite element analysis, the best scaffold configuration is identified and was fabricated with different build orientation using Selective Laser Sintering (SLS) process with different mix of Polyamide and Hydroxyapatite.
Journal ArticleDOI
Three types of dermal grafts in rats: the importance of mechanical property and structural design
TL;DR: Tissue regeneration requires the proper pore size and an appropriate mechanical property like PMCS which could satisfy these conditions to sustain growth, and the mechanical properties of scaffolds are important for maintaining the three-dimensional microarchitecture of constructs used to induce tissue regeneration and vascularization.
Journal ArticleDOI
A hierarchical scaffold with a highly pore-interconnective 3D printed PLGA/n-HA framework and an extracellular matrix like gelatin network filler for bone regeneration.
TL;DR: In this article, a hierarchical polylactic acid glycolic acid copolymer (PLGA)/nano-hydroxyapatite (n-HA)/gelatin (Gel) (PHG) scaffold with a printed PLGA/nHA (PH) framework and a Gel network filler for bone regeneration by the combination of 3D printing and freeze-drying technologies.
Journal ArticleDOI
A time-dependent mechanobiology-based topology optimization to enhance bone growth in tissue scaffolds.
Chi Wu,Jianguang Fang,Ali Entezari,Guangyong Sun,Michael V. Swain,Yanan Xu,Grant P. Steven,Qing Li +7 more
TL;DR: In this paper, a time-dependent mechanobiology-based topology optimization framework was proposed for the design of tissue scaffolds, thereby developing an ongoing favorable microenvironment and ensuring a long-term outcome for bone regeneration.
References
More filters
Journal ArticleDOI
Scaffolds in tissue engineering bone and cartilage.
TL;DR: Research on the tissue engineering of bone and cartilage from the polymeric scaffold point of view is reviews from a biodegradable and bioresorbable perspective.
Journal ArticleDOI
The Design of Scaffolds for Use in Tissue Engineering. Part I. Traditional Factors
TL;DR: The authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods.
Journal ArticleDOI
Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering.
J. M. Williams,Adebisi Adewunmi,Rachel M. Schek,Colleen L. Flanagan,Paul H. Krebsbach,Stephen E. Feinberg,Scott J. Hollister,Suman Das +7 more
TL;DR: The integration of scaffold computational design and free-form fabrication techniques presented here could prove highly useful for the construction of scaffolds that have anatomy specific exterior architecture derived from patient CT or MRI data and an interior porous architecturederived from computational design optimization.
Journal ArticleDOI
Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds.
TL;DR: Solid freeform fabrication (SFF) uses layer-manufacturing strategies to create physical objects directly from computer-generated models to enable the cells to behave in the required manner to produce tissues and organs of the desired shape and size.
Journal ArticleDOI
Mechanotransduction and the functional response of bone to mechanical strain
TL;DR: Mechanotransduction plays a crucial role in the physiology of many tissues including bone and some hormones may interact with local mechanical signals to change the sensitivity of the sensor or effector cells to mechanical load.