Journal ArticleDOI
Fluorometric assay of histamine in tissues and body fluids: Choice of the purification procedure and identification in the nanogram range
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Several procedures for the isolation of histamine from tissues and body fluids were examined in this paper, including thin-layer chromatography on cellulose, inactivation in the presence of purified diamine oxidase from pig kidney and purified histamine methyltransferase from guinea-pig brain, by the biological activities and by the fluorescence spectra of the condensation product between histamine and o-phthaldialdehyde.Abstract:
Several procedures for the isolation of histamine from tissues and body fluids were examined For the fluorometric assay of histamine concentrations higher than 1 μg/g tissue or ml blood the extraction into n-butanol as well as the cation-exchange chromatography on Dowex 50W-X8 proved suitable The determination of histamine in whole blood of dogs gave valid results only after chromatography on Dowex 50, in human plasma and gastric juice only after the combined application of both purification methods Histamine was identified by thin-layer chromatography on cellulose, by inactivation in the presence of purified diamine oxidase from pig kidney and purified histamine methyltransferase from guinea-pig brain, by the biological activities and by the fluorescence spectra of the condensation product between histamine and o-phthaldialdehyde Histamine concentrations in tissues and body fluids of man and some laboratory animals are reportedread more
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Histamine release in man by propanidid and thiopentone: pharmacological effects and clinical consequences
Wilfried Lorenz,A. Doenicke,R. Meyer,H. J. Reimann,J. Kdsche,H. Barth,H. Geesing,M. Hutzel,B. Weissenbacher +8 more
TL;DR: It was shown that release of histamine followed injection of propanidid and thiopentone and that premedication with glucocorticoids and anti-histaminics and therapy with plasma substitutes could prevent the development of a severe reaction.
Journal ArticleDOI
Definition and Classification of the Histamine-Release Response to Drugs in Anaesthesia and Surgery: Studies in the Conscious Human Subject* **
TL;DR: The average histamine-release response was defined by clinical signs such as tachycardia and mild hypertension, scattered hives such as spots of erythema and wheals, respiratory symptoms in the laryngeal and nasal region, such as cough, narrowness in the throat, stuffy nose and sneezing and by pathological plasma histamine levels (>1 ng/ml.
Journal ArticleDOI
Histamine release in man.
TL;DR: Histamine release in man could be demonstrated using the fluorometric histamine assay in plasma as a reliable test and this led to a much better understanding of histamine-induced reactions in human subjects than other techniques and increase the possibility to differentiate between histamine -induced reactions and anaphylactoid reactions caused by other mediators.
Journal ArticleDOI
H1 + H2-receptor antagonists for premedication in anaesthesia and surgery: a critical view based on randomized clinical trials with Haemaccel and various antiallergic drugs.
Wilfried Lorenz,A. Doenicke,B. Schöning,J. Mamorski,D. Weber,E. Hinterlang,B. Schwarz,E. Neugebauer +7 more
TL;DR: It is concluded that premedication with a combination of H1- and H2-receptor antagonists is indicated due to the high incidence of histamine release during anaesthesia and surgery induced by various drugs and treatments.
Journal ArticleDOI
A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals
TL;DR: Investigation of the occurrence and distribution of histamine in man, various mammals, birds, reptiles, amphibians, bony and cartilaginous fishes, lancelets, tunicates, echinoderms, molluscs, and crustaceans finds that stored histamine probably has a specific function in the gastric mucosa, but not a general function, such as theregulation of ubiquitous metabolic processes or the regulation of microcirculation.
References
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Journal Article
A method for the fluorometric assay of histamine in tissues
TL;DR: Gross dissection of brain showed no marked localization of brain histamine and a sensitive and specific fluorometric method for the estimation of histamine in tissues was described.
Book
Fluorescence assay in biology and medicine
TL;DR: Fluorescence assay in biology and medicine is an assay fororescence-based diagnosis of leukaemia and its role in research and treatment is still under investigation.
Journal ArticleDOI
The distribution and properties of a histamine-methylating enzyme.
Journal ArticleDOI
The pharmacological estimation of adenosine and histamine in blood.
G. S. Barsoum,J. H. Gaddum +1 more
TL;DR: The present work was undertaken with the object of developing sensitive and specific tests for adenosine, and the compounds ofAdenosine which are known to occur in the body, and to the discovery that this substance is normally present in blood.