Journal ArticleDOI
Friedländer reaction on 2-amino-3-cyano-4H-pyrans : Synthesis of derivatives of 4H-pyran [2,3-b] quinoline, new tacrine analogues
A. Martinez‐Grau,J. L. Marco +1 more
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The Friedlander reaction of densely functionalized 2-amino-3-cyano-4H-pyrans (1) with cyclohexanone has afforded in one step and good yield 5.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 1997-12-16. It has received 287 citations till now. The article focuses on the topics: Pyran & Quinoline.read more
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Recent Advances in the Friedländer Reaction
José Marco-Contelles,Elena Pérez-Mayoral,Abdelouahid Samadi,Maria do Carmo Carreiras,Elena Soriano +4 more
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Synthesis of halogen derivatives of benzo[h]chromene and benzo[a]anthracene with promising antimicrobial activities.
TL;DR: The synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported and antimicrobial activity was shown for most of the synthesized compounds.
Journal ArticleDOI
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
TL;DR: The concern is growing that AD could better be treated with a single compound targeting two or more of the pathogenic mechanisms leading to neuronal death, and the successful treatment of chronic diseases such as HIV or cancer, with multiple drugs having complementary mechanisms of action.
Journal ArticleDOI
Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents.
TL;DR: A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation, implying a convenient route avoiding the usage of hazardous organic solvents and organic bases.
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DBU: a highly efficient catalyst for one-pot synthesis of substituted 3,4-dihydropyrano[3,2-c]chromenes, dihydropyrano[4,3-b]pyranes, 2-amino-4H-benzo[h]chromenes and 2-amino-4H benzo[g]chromenes in aqueous medium
TL;DR: In this paper, the authors reported DBU catalyzed one-pot synthesis of 3,4-dihydropyrano[3,2-c]chromenes, dihydropyrane[4,3-b]pyranes, 2-amino-4H-benzo[h]chromene and 2-AMino- 4H-bennzo[g]-chromenes from aldehydes.
References
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Carbon-13 nuclear magnetic resonance for organic chemists
George C. Levy,Gordon L. Nelson +1 more
TL;DR: In this paper, the effect of further substitution of the heteroatom X of the P=X bond on the structure of the molecule and the spectral characteristics has been investigated and an experimental study of their vibrational spectra has been made and for selected models of (I) a calculation of the frequencies and modes of the normal vibrations has been carried out by means of a computer program.
Journal ArticleDOI
Advances in Organic Chemistry
TL;DR: Advances in Organic Chemistry Methods and Results, Vol 3 Edited by Ralph A Raphael, Edward C Taylor and Hans Wynberg Pp vii + 333 105s (New York and London: Interscience Publishers, a Division of John Wiley and Sons, Inc, 1963) as mentioned in this paper
Journal ArticleDOI
Tacrine: First Drug Approved for Alzheimer's Disease
TL;DR: Tacrine is the first drug approved by the FDA for treatment of Alzheimer's disease and has been shown to have efficacy in mildly to moderately impaired Alzheimer's patients on both psychometric testing and a clinician's structured interview.
Journal ArticleDOI
Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching
Shaomeng Wang,George W. A. Milne,Xinjian Yan,Isadora J. Posey,Marc C. Nicklaus,Lisa Graham,William G. Rice +6 more
TL;DR: Fifteen novel non-peptide HIV-1 protease inhibitors were identified by flexible 3D database pharmacophore searching of the NCI DIS3D database by using X-ray determined structures of protease/inhibitor complexes.
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