Journal ArticleDOI
Garlic: a review of its relationship to malignant disease.
Judith G. Dausch,Daniel W. Nixon +1 more
TLDR
Some of the physiological characteristics of garlic are reviewed and Hypotheses regarding the possible role of garlic in modulating mechanisms that may alter the carcinogenic process are discussed.About:
This article is published in Preventive Medicine.The article was published on 1990-05-01. It has received 136 citations till now. The article focuses on the topics: Allium sativum & Detoxification.read more
Citations
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Journal ArticleDOI
Health-promoting properties of common herbs
TL;DR: The volatile essential oils of commonly used culinary herbs, spices, and herbal teas inhibit mevalonate synthesis and thereby suppress cholesterol synthesis and tumor growth.
Journal ArticleDOI
The Organosulfur Chemistry of the Genus Allium – Implications for the Organic Chemistry of Sulfur
TL;DR: A Cook's tour of the organosulfur chemistry of the genus Allium, as represented, inter alia, by garlic (Allium sativum L.) and onion(Allium cepa L.). as discussed by the authors reported on the biosynthesis of the S-alk(en)yl-L-cysteine S-oxides (aroma and flavor precursors) in intact plants and on how upon cutting or crushing the plants these precursor are cleaved by allinase enzymes, giving sulfenic acids.
Journal ArticleDOI
Herb-drug interactions: a literature review.
Zeping Hu,Xiaoxia Yang,Paul C. Ho,Sui Yung Chan,Paul Wan Sia Heng,Eli Chan,Wei Duan,Hwee-Ling Koh,Shu-Feng Zhou +8 more
TL;DR: An extensive review of the literature identified reported herb-drug interactions with clinical significance, although the underlying mechanisms for the altered drug effects and/or concentrations by concomitant herbal medicines are yet to be determined.
Journal ArticleDOI
Cholesterol-Lowering Effect of Garlic Extracts and Organosulfur Compounds: Human and Animal Studies
Yu-Yan Yeh,Lijuan Liu +1 more
TL;DR: The results of these studies indicate that the cholesterol-lowering effects of garlic extract, such as AGE, stem in part from inhibition of hepatic cholesterol synthesis by water-soluble sulfur compounds, especially SAC.
Journal ArticleDOI
Herbal Modulation of P‐Glycoprotein
TL;DR: The inhibition of PGP by herbal constituents may provide a novel approach for reversing multidrug resistance in tumor cells, whereas the stimulation of Pgp expression or activity has implication for chemoprotective enhancement by herbal medicines.
References
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Journal Article
Chemoprevention of Cancer
TL;DR: This Perspective deals with the areas in cancer control that this field addresses, the promise that it holds, and the problems that must be solved in order to realize its goals.
Journal ArticleDOI
Allicin, the Antibacterial Principle of Allium sativum. I. Isolation, Physical Properties and Antibacterial Action
Journal ArticleDOI
A new, quantitative, approach to the study of the stages of chemical cartinogenesis in the mouse's skin.
I Berenblum,P Shubik +1 more
TL;DR: A New, Quantitative, Approach to the Study of the Stages of Chemical Carcinogenesis in the Mouse's Skin and its Applications is presented.
Journal Article
Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.
TL;DR: The role of P-450 enzymes in the metabolism of chemical carcinogens was investigated in the early 1990s as discussed by the authors, when the first characterization of the cytochrome P450 enzyme system was presented.
Journal ArticleDOI
Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse
TL;DR: The fact that in the lung the monosulfide and disulfide inhibited, but the trisulfide did not inhibit, indicates that the number of sulfur atoms in the molecule can control the organ sites at which protection against carcinogenesis will occur.