Patent
Gene de susceptibilite a la sitosterolemie (ssg): compositions et methodes d'utilisation
Joshua Schultz,Bei Shan,Hui Tian +2 more
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TLDR
The authors concerne des acides nucleiques codant un nouveau transporteur de cholesterol de la famille ABC, le SSG, and les sequences peuvent etre utilisees a des fin tres variees, y compris pour le diagnostic and le traitement de troubles lies au cholesterol, comprenant la sitosterolemie, ainsi que pour l'identification de molecules associees a l'activite de SSG and/ou la modulant.Abstract:
L'invention concerne des acides nucleiques codant un nouveau transporteur de cholesterol de la famille ABC, le SSG. Selon l'invention, les sequences peuvent etre utilisees a des fins tres variees, y compris pour le diagnostic et le traitement de troubles lies au cholesterol, comprenant la sitosterolemie, ainsi que pour l'identification de molecules associees a l'activite de SSG et/ou la modulant.read more
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Journal ArticleDOI
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
Mi-Hye Lee,Kangmo Lu,Star Hazard,Hongwei Yu,Sergey Shulenin,Hideki Hidaka,Hideto Kojima,Rando Allikmets,Nagahiko Sakuma,R.J. Pegoraro,Anand Srivastava,Gerald Salen,Michael Dean,Shailendra B. Patel +13 more
TL;DR: A new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients and is reported to have a subtle mechanism that allows the body to distinguish between cholesterol and non-cholesterol sterols.
Journal ArticleDOI
ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport
Jochen Klucken,Christa Büchler,Evelyn Orsó,Wolfgang E. Kaminski,Mustafa Porsch-Özcürümez,Gerhard Liebisch,Michael Kapinsky,Wendy Diederich,Wolfgang Drobnik,Michael Dean,Rando Allikmets,Gerd Schmitz +11 more
TL;DR: It is reported here that the ATP-binding cassette (ABC) transporter ABCG1 (ABC8) is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein, defining a biologic activity for ABC transporters in Macrophages.
Journal ArticleDOI
Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21.
Shailendra B. Patel,Gerald Salen,H. Hidaka,P. O. Kwiterovich,Anton F. H. Stalenhoef,Tatu A. Miettinen,Scott M. Grundy,M.-H. Lee,J. S. Rubenstein,Mihael H. Polymeropoulos,Michael J. Brownstein +10 more
TL;DR: Identification of the genetic defect to chromosome 2p21 may throw light on regulation of net dietary cholesterol absorption and lead to an advancement in the management of this important cardiovascular risk factor.
Journal ArticleDOI
Sequence analysis of a 33.2 kb segment from the left arm of yeast chromosome XV reveals eight known genes and ten new open reading frames including homologues of ABC transporters, inositol phosphatases and human expressed sequence tags.
TL;DR: Computer analysis of the complete nucleotide sequence of a 33 221 bp segment derived from the left arm of chromosome XV of Saccharomyces cerevisiae revealed the presence of the previously known genes IRA2, DEC1, NUF2, HST1, RTG1, RIB2 and HAL2, one previously partially sequenced open reading frame (ORF) of unknown function (SCORFAC) and ten newly identified ORFs.