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Gerald Salen
Researcher at Rutgers University
Publications - 239
Citations - 13423
Gerald Salen is an academic researcher from Rutgers University. The author has contributed to research in topics: Bile acid & Cholesterol. The author has an hindex of 62, co-authored 239 publications receiving 12925 citations. Previous affiliations of Gerald Salen include University of Pennsylvania & United States Department of Veterans Affairs.
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Journal ArticleDOI
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
Mi-Hye Lee,Kangmo Lu,Star Hazard,Hongwei Yu,Sergey Shulenin,Hideki Hidaka,Hideto Kojima,Rando Allikmets,Nagahiko Sakuma,R.J. Pegoraro,Anand Srivastava,Gerald Salen,Michael Dean,Shailendra B. Patel +13 more
TL;DR: A new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients and is reported to have a subtle mechanism that allows the body to distinguish between cholesterol and non-cholesterol sterols.
Journal ArticleDOI
Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
Clive R. Pullinger,Celeste Eng,Gerald Salen,Sarah Shefer,Ashok K. Batta,Sandra K. Erickson,Andrea Verhagen,Christopher R. Rivera,Sean J. Mulvihill,Mary J. Malloy,John P. Kane +10 more
TL;DR: A new metabolic disorder presenting with hyperlipidemia caused by a homozygous deletion mutation in CYP7A1 is reported, which leads to a frameshift that results in loss of the active site and enzyme function.
Journal ArticleDOI
Metabolism of beta-sitosterol in man.
TL;DR: Values of turnover for β-sitosterol obtained by the sterol balance method agreed closely with those derived by use of the two-pool model, hence, daily turnover of β- sitosterol equaled its daily absorption.
Journal Article
Interruption of the enterohepatic circulation of bile acids in man: comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism.
Journal ArticleDOI
Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.
Kangmo Lu,Mi Hye Lee,Starr Hazard,Angela Brooks-Wilson,Hideki Hidaka,Hideto Kojima,Leiv Ose,Anton F. H. Stalenhoef,Tatu Mietinnen,Ingemar Björkhem,Eric Bruckert,Arti Pandya,H. Bryan Brewer,Gerald Salen,Michael Dean,Anand Srivastava,Shailendra B. Patel +16 more
TL;DR: Two highly homologous genes, located in a head-to-head configuration on chromosome 2p21, are involved as causes of sitosterolemia, and studies indicate that both sterolin-1 and sterol-2 are indispensable for the regulation of sterol absorption and excretion.