Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study.
Daniel Woo,Laura Sauerbeck,Brett M. Kissela,Jane Khoury,Jerzy P. Szaflarski,James Gebel,Rakesh Shukla,Arthur M. Pancioli,Edward C. Jauch,Anil G. Menon,Ranjan Deka,Janice Carrozzella,Charles J Moomaw,Robert N. Fontaine,Joseph P. Broderick +14 more
TLDR
In this paper, the authors report a preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of ICH.Abstract:
Background and Purpose— Intracerebral hemorrhage (ICH) has a 30-day mortality rate of 40% to 50% and lacks a proven treatment. We report a preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of ICH. Methods— We prospectively identified cases of hemorrhagic stroke at all 16 hospitals in the Greater Cincinnati/Northern Kentucky region. All cases underwent medical record and neuroimaging review. Cases enrolled in the direct interview and genetic sampling arm of the study were matched to population-based control subjects by age, race, and sex. Multivariable logistic regression was performed to identify significant independent risk factors. Results— We enrolled 188 cases of ICH (67 lobar, 121 nonlobar) and 366 control subjects in the direct interview arm of the study. Significant independent risk factors for lobar ICH included the presence of an apolipoprotein E2 or E4 allele, frequent alcohol use, prior stroke, and first-deg...read more
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Guidelines for the Management of Spontaneous Intracerebral Hemorrhage. A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
J. Claude Hemphill,Steven M. Greenberg,Craig S. Anderson,Kyra J. Becker,Bernard R. Bendok,Mary Cushman,Gordon L. Fung,Joshua N. Goldstein,R. Loch Macdonald,Pamela H. Mitchell,Phillip A. Scott,Magdy Selim,Daniel Woo +12 more
TL;DR: In this article, the authors present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous intracerebral hemorrhage, including diagnosis, hemostasis, blood pressure management, inpatient and nursing management, preventing medical comorbidities, surgical treatment, outcome prediction, rehabilitation, prevention of recurrence and future considerations.
Journal ArticleDOI
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage
Lewis B. Morgenstern,J. Claude Hemphill,Craig S. Anderson,Kyra J. Becker,Joseph P. Broderick,E. Sander Connolly,Steven M. Greenberg,James N. Huang,R. Loch Macdonald,Steven R. Messé,Pamela H. Mitchell,Magdy Selim,Rafael J. Tamargo +12 more
TL;DR: In this article, the authors present current and comprehensive recommendations for the diagnosis and treatment of spontaneous intracerebral hemorrhage, and a formal literature search is performed to identify the cause of the hemorrhage.
Journal ArticleDOI
Mechanisms of brain injury after intracerebral haemorrhage
TL;DR: The coagulation cascade, haemoglobin breakdown products, and inflammation all play a part in ICH-induced injury and could provide new therapeutic targets and new therapeutic interventions for this severe form of stroke.
Journal ArticleDOI
Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group.
Joseph P. Broderick,Sander Connolly,Edward Feldmann,Daniel F. Hanley,Carlos S. Kase,Derk Krieger,Marc R. Mayberg,Lewis B. Morgenstern,Christopher S. Ogilvy,Paul M. Vespa,Mario Zuccarello +10 more
TL;DR: Evidence-based guidelines are presented for the diagnosis of intracerebral hemorrhage, the management of increased arterial blood pressure and intracranial pressure, the treatment of medical complications of intrusion, and the prevention of recurrent intrusion.
Journal ArticleDOI
Prevalence and risk factors of cerebral microbleeds The Rotterdam Scan Study
Meike W. Vernooij,A. van der Lugt,M. A. Ikram,Piotr A. Wielopolski,Wiro J. Niessen,Albert Hofman,Gabriel P. Krestin,Monique M.B. Breteler +7 more
TL;DR: The data support the hypothesis that strictly lobar microbleeds are related to cerebral amyloid angiopathy, whereas microbleed in a deep or infratentorial location result from hypertensive or atherosclerotic microangiopathy.
References
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Statistical Methods for Rates and Proportions
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TL;DR: awareness, treatment, and control of hypertension have improved substantially since the 1976-1980 National Health and Nutrition Examination Survey but continue to be suboptimal, especially in Mexican Americans.(ABSTRACT TRUNCATED AT 250 WORDS)
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Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
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