Genetic control of cytolytic t-lymphocyte responses. II. The role of the host genotype in parental leads to F1 radiation chimeras in the control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.
TLDR
It is demonstrated that the host environment where T cells differentiate influences the specificity of the primary cytolytic T-lymphocyte (CTL) response to TNP-modified syngeneic antigens.Abstract:
Bone marrow cells from C3H (H-2k) mice, a strain that does not exhibit cross-reactive lysis of trinitrophenyl (TNP)-modified allogeneic targets, were allowed to mature in heavily irradiated (B6 times C3H)F1 (H-2b/k) recipients, an F1 hybrid that does demonstrate cross-reactive lysis. Spleen cells from these chimeric mice were removed after 3-4 mo and by H-2 typing shown to be of C3H origin. These cells were found to be tolerant to B6 alloantigens by mixed lymphocyte reaction and cell-mediated cytotoxicity and, when stimulated in vitro with TNP-modified syngeneic cells, now cross-reactively lysed TNP-modified allogeneic targets. These studies demonstrate that the host environment where T cells differentiate influences the specificity of the primary cytolytic T-lymphocyte (CTL) response to TNP-modified syngeneic antigens.read more
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Book ChapterDOI
Ir Genes, Adaptive Differentiation and Self-Recognition
TL;DR: It is now established that the self-recognition repertoire by which interacting lymphoid cells perceive themselves most efficiently is influenced significantly by elements in the environmental milieu to which developing cells are exposed during their early differentiation.
Book ChapterDOI
Mhc-restriction and differentiation of t cells1
TL;DR: How Τ cells acquire specificity for self-Η during ontogeny has been the focus of several experiments with chimeras formed either by reconstituting lethally irradiated mice with lymphohemopoietic stem (bone marrow) cells from various sources or by reconStituting mice lacking a thymus andΤ cells with thymUS grafts.
Journal ArticleDOI
The H‐2 Restriction Specificity of Cytotoxic T Cells Derived from Intrathymic Precursors
Mikko Hurme,M. Sihvola +1 more
TL;DR: The data suggest that the H‐2 restriction specificity is dictated before or at the same time that the cell acquires capacity to respond to allogeneic or haptenated syngeneic cells.