PatentDOI
Hadamard transform measurement of MSN Fourier-transform mass spectra
TLDR
In this article, the product relationships are coded by a Hadamard differences method, where the combined daughter spectrum of a selected half of the precursors is subtracted from the combined spectrum of the remaining precurors, so that no ions are lost.Abstract:
The simultaneous collection of multiple spectra using tandem and multidimensional mass spectrometry from multiple precursors yields correspondingly enhanced sensitivity through Hadamard transform deconvolution. For MS n spectra, the product relationships are coded by a Hadamard differences method wherein the combined daughter spectrum of a selected half of the precursors is subtracted from the combined daughter spectrum of the remaining precursors, so that no ions are lost.read more
Citations
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Journal ArticleDOI
Fourier transform ion cyclotron resonance mass spectrometry: A primer
TL;DR: This review offers an introduction to the principles and generic applications of FT-ICR mass spectrometry, directed to readers with no prior experience with the technique, and lists accurate fundamental constants needed for ultrahigh-precision analysis.
Journal ArticleDOI
Electron Capture Dissociation of Gaseous Multiply-Charged Proteins Is Favored at Disulfide Bonds and Other Sites of High Hydrogen Atom Affinity
Roman A. Zubarev,Nathan A. Kruger,Einar K. Fridriksson,Mark A. Lewis,David M. Horn,Barry K. Carpenter,Fred W. McLafferty +6 more
TL;DR: RRKM calculations indicate that H• capture Dissociation of backbone bonds in multiply-charged proteins represents nonergodic behavior, as proposed for the original direct mechanism of electron capture dissociation.
Journal ArticleDOI
The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS/MS.
Scott J. Geromanos,Johannes P. C. Vissers,Jeffrey C. Silva,Jeffrey C. Silva,Craig A. Dorschel,Guo-Zhong Li,Marc V. Gorenstein,Robert Harold Bateman,James I. Langridge +8 more
TL;DR: The presented data illustrates that the time‐aligned data from data‐independent alternate scanning LC‐MS experiments is highly comparable to the data obtained via DDA, and can therefore be effectively and correctly deconvolved to correlate product ions with parent precursor ions.
Journal ArticleDOI
Milestones in fourier transform ion cyclotron resonance mass spectrometry technique development
TL;DR: The present range and power of Fourier transform ion cyclotron resonance mass spectrometry rest on a number of prior technique developments as mentioned in this paper, which can resolve and identify up to thousands of components of a complex mixture, often without prior wet chemical separation, thereby potentially changing the whole approach to dealing with chemical and biological complexity.
Journal ArticleDOI
Multiplexed MS/MS for improved data-independent acquisition
Jarrett D. Egertson,Andreas Kuehn,Gennifer E. Merrihew,Nicholas W. Bateman,Brendan MacLean,Ying S. Ting,Jesse D. Canterbury,Donald M Marsh,Markus Kellmann,Vlad Zabrouskov,Christine C. Wu,Michael J. MacCoss +11 more
TL;DR: A multiplexing strategy is demonstrated for DIA analysis that increases precursor selectivity fivefold and can be used for data-dependent acquisition or selected reaction monitoring.
References
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Fourier Transform Ion Cyclotron Resonance Spectroscopy
TL;DR: The Fourier transform ion cyclotron resonance (FT-ICR) 1.5 mass spectrometer as discussed by the authors was developed for mass spectroscopy and it can be used to obtain the whole spectrum in a very short period of time.