Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.
Aysel Vehapoglu,Gamze Ozgurhan,Aysegul Dogan Demir,Selcuk Uzuner,Mustafa Atilla Nursoy,Serdar Turkmen,Arzu Kacan +6 more
Reads0
Chats0
TLDR
The Mentzer index was the most reliable index, as it had the highest sensitivity, specificity, and Youden's index for detecting β-TT for detecting IDA and this was followed by the Ehsani index.Abstract:
Background. The two most frequent types of microcytic anemia are beta thalassemia trait (β-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and β-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1–16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7–11.4 g/dL. None of the subjects had a combined case of IDA and β-TT. All children with IDA received oral iron for 16 weeks, and HbA2 screening was performed after iron therapy. The patient groups were evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lal, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden’s index (81%) for detecting β-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion. The Mentzer index provided the highest reliabilities for differentiating β-TT from IDA.read more
Citations
More filters
Journal ArticleDOI
Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia: a reply
TL;DR: The ratio of microcytic to hypochromic RBCs (M/H ratio) showed the best performance and outperformed all other discriminant indices for discriminating between iron deficiency anemia and thalassemia trait.
Journal ArticleDOI
Detection of β thalassemia carriers by red cell parameters obtained from automatic counters using mathematical formulas
TL;DR: A reliable formula is found that can be incorporated into any automatic blood counter to alert health providers to the possibility of a woman being a β-thalassemia carrier and is limited to women of fertility age until further analysis in other groups can be performed.
Journal ArticleDOI
Differentiation of beta thalassemia trait from iron deficiency anemia by hematological indices.
TL;DR: RDWI is a reliable and useful index for differentiation among IDA and βTT, as compared to RDW, which showed better sensitivity and specificity for βTT.
Journal ArticleDOI
Red Cell Indices and Formulas Used in Differentiation of β-Thalassemia Trait from Iron Deficiency in Thai Adults.
Soontharee Plengsuree,Manoo Punyamung,Jintana Yanola,Siriporn Nanta,Kanokwan Jaiping,Kritsanee Maneewong,Sanchai Wongwiwatthananukit,Sakorn Pornprasert +7 more
TL;DR: The RDW/RBC formula proved to be the most reliable index as they had 100.0% specificity and PPV and the highest efficiency and Youden’s Index, and could be used in initial discrimination of β-thal trait from iron deficiency in adult Thai subjects.
Journal ArticleDOI
Reduced red blood cell count predicts poor survival after surgery in patients with primary liver cancer.
Xiaomeng Xie,Mingjie Yao,Xiangmei Chen,Weiquan Lu,Quanjun Lv,Kaijuan Wang,Ling Zhang,Fengmin Lu +7 more
TL;DR: It is revealed that patients with preoperative RBC counts lower than normal had worse OS rates than those without reduced preoperativeRBC counts, perhaps due to the significant correlation of reduced pre operative RBC count to patients’ worse Child–Pugh grade that reflect the loss of liver functions.
References
More filters
Journal ArticleDOI
Biochemical Markers and Hematologic Indices in the Diagnosis of Functional Iron Deficiency
Christian Thomas,Lothar Thomas +1 more
TL;DR: In APR patients, biochemical markers demonstrate weaknesses in the diagnosis of functional ID as defined by hematologic indices, and use of diagnostic plots to illustrate the relationship between the sTfR-F index and CHr allows the progression of ID to be identified, regardless of whether an APR is present.
Journal ArticleDOI
Most reliable indices in differentiation between thalassemia trait and iron deficiency anemia
TL;DR: This work has shown that Youden's index is the most reliable method by which to measure the validity of a particular technique, because it takes into account both sensitivity and specificity.
Journal ArticleDOI
Differentiation of iron deficiency from thalassaemia trait by routine blood-count.
J.M. England,PatriciaM. Fraser +1 more
TL;DR: In 72 patients presenting with microcytosis, a simple discriminant function derived from the mean cell volume and the haemoglobin concentration correctly identified all but one of the cases studied (99%).
Journal ArticleDOI
The effect of iron deficiency anaemia on the levels of haemoglobin subtypes: possible consequences for clinical diagnosis.
TL;DR: The purpose of the present study was to quantify the effect of iron deficiency anaemia on the levels of HbA2, HbF, and HBA1C, and to suggest that iron deficiency must be corrected before making any diagnostic or therapeutic decisions based on Hb a1C levels.