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Herbal remedies and other risk factors for preterm birth in rural Kenya

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TLDR
Herbal use in pregnancy regardless of gestation, previous pre term birth and low socio-economic status and are risk factors for preterm birth in Kitui County Kenya.
Abstract
Background: Premature infants contribute substantially to infant morbidity and mortality especially in low resource settings.  Information on herbal remedy use, previous preterm birth and low social-economic status and their association with incidence of preterm birth in Kenya is scanty. Objectives : To determine the use of herbal remedy use in pregnancy, previous preterm birth and low socio-economic status as risk factors for Preterm Birth in Kitui County among the immediate post-partum mothers. Methods: Unmatched case control study with a 1:4 ratio of cases to controls. The study was done in Kitui and Mwingi District Hospitals.  A total of 107 mothers with preterm birth (cases) and 453 mothers with term births (controls) were eligible and administered structured interviews. Results: Of the sample, 98% of cases resided in rural areas compared to 90% of controls.  The cases had a higher parity and were more likely to belong to the lowest three and four levels of socio-economic status. On multivariate logistic regression analysis, predictors of preterm birth were: preeclampsia (OR=9.06 [2.60-31.63], p=0.001), previous preterm, (OR=9.31 [2.82-30.68], p<0.001), low socioeconomic status (OR=1.51 [1.05-2.16], p=0.03), herbal use in first trimester for 2-5 days (OR=11.10 [4.34-28.41], p<0.001), herbal use in first trimester for 6-10 days (OR=44.87,[4.99-403.87] p=0.001), and herbal use in second trimester for 6-10 days (OR=16.43 [4.53-59.57], p<0.001). Use of prescribed folic acid in second trimester for more than 31 days was associated with lower risk of preterm birth (OR=0.20 [0.12-0.34], p<0.001). Conclusion: Herbal use in pregnancy regardless of gestation, previous preterm birth and low socio-economic status and are risk factors for preterm birth in Kitui County Kenya.  Interventions targeted to reduction of these risk factors will be an important additional prong in the reduction of preterm birth. Key words : Preterm birth, herbal remedy, risk factors

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Determinants of Preterm Birth among Women Who Gave Birth in Amhara Region Referral Hospitals, Northern Ethiopia, 2018: Institutional Based Case Control Study.

TL;DR: Most of the determinants of preterm birth found to be modifiable and putting emphasis for prevention of obstetric and gynecologic complications such as anemia, premature rupture of membrane and abortion would decrease the incidence of pre term birth.
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Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention.

TL;DR: New alternative strategies involving the use of PDE-4 inhibitors, medicinal plants and probiotics could have a great impact for improving prenatal and neonatal outcomes and give babies the best start in life, ensuring lifelong health benefits.
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Exploring cultural determinants to be integrated into preterm infant care in the neonatal intensive care unit: an integrative literature review

TL;DR: In this paper , the authors synthesize literature on the cultural determinants that can be integrated into care of preterm infants admitted into the neonatal intensive care unit (NICU).
References
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Journal ArticleDOI

Epidemiology and causes of preterm birth

TL;DR: A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth.
Journal ArticleDOI

The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity

TL;DR: Developing countries, especially those in Africa and southern Asia, incur the highest burden in terms of absolute numbers, although a high rate is also observed in North America.
Journal Article

The Worldwide Incidence of Preterm Birth: A Systematic Review of Maternal Mortality and morbidity/Incidence Mondiale De la Missance Avant Terme: Revue Sytemtique De la Mortalite et De la Morbidite maternelle/Incidencia Mundial De Parto Prematuro: Revision Sistematica De la Morbilidad Y Mortalidad Maternas

TL;DR: Preterm birth, defined as childbirth occurring at less than 37 completed weeks or 259 days of gestation, is a major determinant of neonatal mortality and morbidity and has long-term adverse consequences for health as mentioned in this paper.
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