Journal ArticleDOI
High content of zerumbone in volatile oils of Zingiber zerumbet from southern India and Malaysia
Sabulal Baby,Mathew Dan,Abdul Rasheed Muhammed Thaha,Anil John Johnson,Rajani Kurup,Prasanth Balakrishnapillai,Chong Keat Lim +6 more
TLDR
In this paper, the chemical profiles of volatile oils of Z. zerumbet rhizomes from six locations in the southern Indian state of Kerala and also from Penang in Malaysia were reported.Abstract:
Zerumbone is a sesquiterpene phytochemical with potential anticancer, anti-inflammatory, anti-HIV and other biological activities, most abundantly found in Zingiber zerumbet (L.) Smith. Previous studies reported 12.6–73.1% of zerumbone in Z. zerumbet rhizome oils from various geographical locations. In a careful review of the literature, we found that most of the previous gas chromatographic profiling studies on volatile oils of Z. zerumbet were inadequate, since they were based on poor identification and quantification procedures and also on single-sample data. In this study, we report the chemical profiles of volatile oils of Z. zerumbet rhizomes from six locations in the southern Indian state of Kerala and also from Penang in Malaysia. Chemical profiling of volatiles was carried out by extensive GC–FID, GC–MS and associated techniques, supported by 1H-NMR, 13C-NMR, FABMS and HPTLC. The full chemical profiles of rhizome oils of these seven accessions of Z. zerumbet were elucidated. The south Indian accessions of Z. zerumbet reported 76.3–84.8% zerumbone content in their rhizome oils. The Malaysian accession recorded the lowest content of zerumbone (68.9%). This study reveals the high content of the bioactive compound zerumbone in Z. zerumbet from Kerala. Copyright © 2009 John Wiley & Sons, Ltd.read more
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ZnO-Ag core shell nanocomposite formed by green method using essential oil of wild ginger and their bactericidal and cytotoxic effects
Susan Azizi,Rosfarizan Mohamad,Raha Abdul Rahim,Amin Boroumand Moghaddam,Mona Moniri,Arbakariya B. Ariff,Wan Zuhainis Saad,Farideh Namvab +7 more
TL;DR: In this article, a green method for fabrication of zinc oxide-silver (ZnO-Ag) core-shell nanocomposite using essential oil of ginger (EO-G) is reported.
Journal ArticleDOI
Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials
Heshu Sulaiman Rahman,Abdullah Rasedee,Swee Keong Yeap,Hemn Hassan Othman,Max Stanley Chartrand,Farideh Namvar,Ahmad Bustamam Abdul,Chee Wun How +7 more
TL;DR: Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER.
Journal ArticleDOI
Several aspects of Zingiber zerumbet: a review
TL;DR: The aim of this review is to provide a overview about the main aspects related with pharmacognosy and pharmacology of Z. zerumbet published in the literature over the last decade.
Journal ArticleDOI
Studies on α-glucosidase, aldose reductase and glycation inhibitory properties of sesquiterpenes and flavonoids of Zingiber zerumbet Smith.
K.R. Ajish,Kalathookunnel Antony Antu,Mariam Philip Riya,M.R. Preetharani,Kozhiparambil Gopalan Raghu,B. P. Dhanya,Kokkuvayil Vasu Radhakrishnan +6 more
TL;DR: Kaempferol and kaEMPferol-3-O-methylether are potent inhibitors of α-glucosidase enzyme, aldose reductase enzyme and glycation reaction, the three main targets of drugs for the treatment of diabetes and its complications.
Journal ArticleDOI
Chemical Constituents of the Root Essential Oils of Zingiber rubens Roxb., and Zingiber zerumbet (L.) Smith
TL;DR: The root essential oils were obtained by water distillation and analyzed by Gas chromatography (GC) and gas chromatography coupled with Mass spectrometry (GC-MS).
References
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A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography.
H. van Den Dool,P. Dec. Kratz +1 more
TL;DR: The equation given by Kovats for the calculation of the retention index in case of isothermal operation is transformed to a more general form to include also the case of linear temperature programmed operation and gives the same retention index for both ways of operation.
Journal ArticleDOI
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the α,β-unsaturated carbonyl group is a prerequisite
Akira Murakami,Daisuke Takahashi,Takashi Kinoshita,Koichi Koshimizu,Ha Won Kim,Akira Yoshihiro,Yoshimasa Nakamura,Suratwadee Jiwajinda,Junji Terao,Hajime Ohigashi +9 more
TL;DR: Zerumbone is a food phytochemical that has distinct potentials for use in anti-inflammation, chemoprevention, and chemotherapy strategies, and alpha-humulene, a structural analog lacking only the carbonyl group in ZER, was virtually inactive in all experiments conducted, indicating that the alpha,beta-unsaturated carbony l group may play some pivotal roles in interactions with unidentified target molecule(s).
Journal ArticleDOI
Ginger: An Ethnomedical, Chemical and Pharmacological Review
TL;DR: Powerful medicinal properties have been recorded for Zingiber officinale, commonly known as ginger, with 99 references to the present status of the plant in the literature with details of individual medicinal activities given.
Journal ArticleDOI
Caryophyllene-rich rhizome oil of Zingiber nimmonii from South India: Chemical characterization and antimicrobial activity
Baby Sabulal,Mathew Dan,Anil John J,Rajani Kurup,Nediyamparambu Sukumaran Pradeep,Renju Krishna Valsamma,Varughese George +6 more
TL;DR: The antimicrobial activity of the oil showed significant inhibitory activity against the fungi, Candida glabrata, C. albicans and Aspergillus niger and the bacteria Bacillus subtilis and Pseudomonas aeruginosa, and no activity was observed against the fungus Fusarium oxysporum.
Journal ArticleDOI
Cytotoxic components of Zingiber zerumbet, Curcuma zedoaria and C. domestica.
TL;DR: One new and five known compounds, which all showed cytotoxic activity, were isolated from the rhizomes of Zingiber zerumbet. The new compound was 3″,4″- O -diacetylafzelin this paper.