Journal ArticleDOI
Host-defence peptides from the glandular secretions of amphibians: structure and activity
TLDR
This review covers the literature on the subject of biologically active peptide from the glands of amphibians, which include neuropeptides, antimicrobial and anticancer active peptides, antiviral agents, fungicides and peptides which complex with Ca2+ calmodulin.About:
This article is published in Natural Product Reports.The article was published on 2006-06-01. It has received 185 citations till now. The article focuses on the topics: Amphibian Proteins.read more
Citations
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Journal ArticleDOI
The emergence of peptides in the pharmaceutical business: From exploration to exploitation
Thomas Uhlig,Themis-Dimitrios Kyprianou,Filippo Giancarlo Martinelli,Carlo Alberto Oppici,Dave Heiligers,Diederik Hills,Xavier Ribes Calvo,Peter Verhaert +7 more
TL;DR: This minireview touches upon the challenges and opportunities peptides experience on the track to become an approved pharmaceutical.
Journal ArticleDOI
Resistance to chytridiomycosis varies among amphibian species and is correlated with skin peptide defenses
Douglas C. Woodhams,Douglas C. Woodhams,Katie Ardipradja,Ross A. Alford,Gerry Marantelli,Laura K. Reinert,Louise A. Rollins-Smith +6 more
TL;DR: Differences in susceptibility to chytridiomycosis among four Australian species after experimental infection with B. dendrobatidis are demonstrated, and it is observed that circulating granulocyte, but not lymphocyte, counts differed between infected and uninfected Lit.
Dissertation
Isolation and characterization of a novel antimicrobial peptide from Bufo bufo gargarizans = 한국산 두꺼비로부터 새로운 항균 펩타이드 분리와 그 특성 연구
Chan-Bae Park,박찬배 +1 more
TL;DR: A potent and structurally novel antimicrobial peptide was isolated and characterized from the stomach tissue of Bufo bufo gargarizans, an Asian toad.
Journal ArticleDOI
The chemistry and biological activities of peptides from amphibian skin secretions.
Xueqing Xu,Ren Lai +1 more
Journal ArticleDOI
Buforins: histone H2A-derived antimicrobial peptides from toad stomach.
TL;DR: Buforins, which house a helix-hinge-helix domain, kill a microorganism by entering the cell without membrane permeabilization and thus binding to nucleic acids, thus making these peptides attractive reagents for pharmaceutical applications.
References
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Journal ArticleDOI
Status and Trends of Amphibian Declines and Extinctions Worldwide
Simon N. Stuart,Janice Chanson,Neil A. Cox,Bruce E. Young,Ana S. L. Rodrigues,Debra L. Fischman,Robert W. Waller +6 more
TL;DR: The first global assessment of amphibians provides new context for the well-publicized phenomenon of amphibian declines and shows declines are nonrandom in terms of species' ecological preferences, geographic ranges, and taxonomic associations and are most prevalent among Neotropical montane, stream-associated species.
Journal ArticleDOI
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
TL;DR: A family of peptides with broad-spectrum antimicrobial activity has been isolated from the skin of the African clawed frog Xenopus laevis and appears to represent a previously unrecognized class of vertebrate antimicrobial activities.
Journal ArticleDOI
Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America.
Lee Berger,Richard Speare,Peter Daszak,D.E. Green,Andrew A. Cunningham,C. L. Goggin,R Slocombe,Mark A. Ragan,Alex D. Hyatt,Keith R. McDonald,Harry B. Hines,Karen R. Lips,Gerry Marantelli,H. Parkes +13 more
TL;DR: Experimental data support the conclusion that cutaneous chytridiomycosis is a fatal disease of anurans, and it is hypothesize that it is the proximate cause of these recent amphibian declines.
Journal ArticleDOI
Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.
TL;DR: This review, which is focused on the different stages of membrane permeation induced by representatives of amphipathic alpha-helical antimicrobial and cell non-selective lytic peptides distinguishes between the 'carpet' mechanism, which holds for antimicrobial peptides versus the 'barrel-stave' mechanisms, which hold for cellnon- selective lytics peptides.
Journal ArticleDOI
A potent and selective endogenous agonist for the mu-opiate receptor.
TL;DR: The discovery and isolation from brain of a peptide, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2), which has the highest specificity and affinity for the µ receptor of any endogenous substance so far described and they maybe natural ligands for this receptor.