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Ian F. Musgrave
Researcher at University of Adelaide
Publications - 112
Citations - 2706
Ian F. Musgrave is an academic researcher from University of Adelaide. The author has contributed to research in topics: Imidazoline receptor & Protein kinase C. The author has an hindex of 27, co-authored 105 publications receiving 2398 citations. Previous affiliations of Ian F. Musgrave include Australian National University & University of Queensland.
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Host-defence peptides from the glandular secretions of amphibians: structure and activity
TL;DR: This review covers the literature on the subject of biologically active peptide from the glands of amphibians, which include neuropeptides, antimicrobial and anticancer active peptides, antiviral agents, fungicides and peptides which complex with Ca2+ calmodulin.
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(−)-Epigallocatechin-3-Gallate (EGCG) Maintains κ-Casein in Its Pre-Fibrillar State without Redirecting Its Aggregation Pathway
TL;DR: It is proposed that EGCG is directed to the amyloidogenic sheet-turn-sheet motif of monomeric RCMkappa-CN with high affinity by strong non-specific hydrophobic associations, and additional non-covalent pi-pi stacking interactions between the polyphenolic and aromatic residues common to theAmyloidsogenic sequence are also implicated.
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Alzheimer disease: amyloidogenesis, the presenilins and animal models.
TL;DR: There is an emphasis on the importance of animal models in elucidating the molecular mechanisms behind the development of Alzheimer's disease and how the zebrafish, Danio rerio, can be used as a model organism for analysis of presenilin function and Alzheimer's Disease pathogenesis.
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Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation.
Yanqin Liu,Tara L. Pukala,Ian F. Musgrave,Danielle M. Williams,Francis C. Dehle,John A. Carver,John A. Carver +6 more
TL;DR: It is shown, using in vitro thioflavin T assays and transmission electron microscopy, that grape seed extract inhibits fibril formation of kappa-casein (κ-CN), a milk protein which forms amyloid fibrils spontaneously under physiological conditions and it is concluded that the gallate moiety has the fibrIL-inhibitory activity.
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Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM).
Megan L. Coghlan,Garth L. Maker,Elly Crighton,James Haile,Dáithí C. Murray,Nicole White,Roger W. Byard,Matthew I. Bellgard,I. Mullaney,Robert D. Trengove,Richard J.N. Allcock,Christine Nash,Claire L. Hoban,Kevin Jarrett,Ross Edwards,Ian F. Musgrave,Michael Bunce +16 more
TL;DR: Next generation DNA sequencing is combined with toxicological and heavy metal screening by separation techniques and mass spectrometry to provide a comprehensive audit of traditional and alternative medicines.