Journal ArticleDOI
Human Glomerular Basement Membrane: Chemical Alteration in Diabetes Mellitus
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TLDR
The human glomerular basement membrane belongs to the collagen family of proteins and contains about 7 percent carbohydrate, half of which occurs as glucosylgalactose disaccharide units linked to hydroxylysine.Abstract:
The human glomerular basement membrane belongs to the collagen family of proteins. It contains about 7 percent carbohydrate, half of which occurs as glucosylgalactose disaccharide units linked to hydroxylysine. Glomeruli from diabetics contain increased amounts of basement membrane material. In addition, these membranes show a distict chemical alteration c haracterized by a significant decrease in lysine, accoumpanied by an equivalent increase in hydroxylysine and hydroxylysine-linked disaccharide units.read more
Citations
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Journal ArticleDOI
Hemoglobin components in patients with diabetes mellitus.
TL;DR: The increase in proportions of glycohemoglobin in diabetes mellitus appears to be another example of increased glycoproteins in this disorder.
Book ChapterDOI
Biochemistry and metabolism of basement membranes.
TL;DR: Basement membranes or basal laminae are ubiquitous in the vertebrate and invertebrate world and constitute important structural and functional extracellular matrices and serve as a boundary between cell types or between cell layers and the underlying connective tissue.
Journal ArticleDOI
Biological significance of the intermolecular crosslinks of collagen.
TL;DR: Current theories of the crosslinks stabilising the collagen fibre are based on the isolation of compounds from borohydride-reduced collagen but what is the evidence for their existence in vivo and what, if any, is the physiological significance of these proposed crosslinks both in normal and pathological conditions?
Journal ArticleDOI
The biosynthesis of collagen. 1.
TL;DR: Micro-Heterogeneity in the Biosynthesis of Collagen Detailed analyses of the structure of the polypeptide chains of collagen has revealed a "micro-heterogeneity" of the amino acid sequences.
Journal ArticleDOI
Polyantigenic expansion of basement membrane constituents in diabetic nephropathy
TL;DR: The immunohistopathology of the intrinsic basement membrane-associated antigens were examined in diabetic nephropathy and document the complexity of polyantigenic alterations in the development of diabetic neephropathy.
References
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Journal ArticleDOI
Studies on the Renal Glomerular Basement Membrane: PREPARATION AND CHEMICAL COMPOSITION
TL;DR: Of interest among the properties of this membrane was its complete solubility under conditions of mild alkaline treatment.
Book ChapterDOI
The structure of collagen and gelatin.
Harrington Wf,Von Hippel Ph +1 more
TL;DR: This chapter reviews that collagen constitutes the major protein component of skin, bone, tendon, and all the other forms of connective tissue and that the collagen ⇆ gelatin transformation in solution has been recognized as a reversible first-order phase transition, subject to the same physical laws which govern the crystalline ⇆ amorphous phase transitions observed in systems of linear polymers.
Journal ArticleDOI
The Structure of the Disaccharide Unit of the Renal Glomerular Basement Membrane
TL;DR: The disaccharide unit of the glomerular basement membrane has been studied in regard to its detailed structure and its linkage to the peptide portion and the anomeric configuration of this linkage was shown to be α on the basis of studies with α- and β-glucosidases.
Journal ArticleDOI
Characterization and Quantitative Determination of the Hydroxylysine-linked Carbohydrate Units of Several Collagens
TL;DR: The hydroxylysine-containing glycopeptides from collagenase-Pronase digests of bovine tendon collagen were found to have glucose and galactose as their monosaccharide components and these results are consistent with a structure for the disaccharides of 2-O-α-d-glucopyranosyl-D-galactose, which is identical with that found for the glomerular basement membrane.
Related Papers (5)
Studies on the Renal Glomerular Basement Membrane: PREPARATION AND CHEMICAL COMPOSITION
Effect of diabetes on the biosynthesis of the renal glomerular basement membrane. Studies on the glucosyltransferase.
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