Journal ArticleDOI
Hyperbaric oxygen therapy. Part 2: application in disease.
TLDR
There is a substantial body of literature that has examined the adverse and beneficial effects of HBOT in animal models and HBOT may be considered as an additional therapeutic option in many conditions including select problem wounds, spinal cord injury, and cerebral ischemic injury.Abstract:
Objective – Review the mechanisms of action and clinical application of hyperbaric oxygen therapy (HBOT) based on human and veterinary clinical and experimental literature.
Data Sources – Pubmed and Veterinary Information Network databases were searched for human and veterinary journal articles on hyperbaric therapy in clinically applicable situations. Historical reference searches on several articles in addition to basic physiologic concepts were also reviewed.
Human Data Synthesis – HBOT has gained acceptance as an adjunctive treatment in clinical conditions other than diving-related injuries, such as select problem wounds and central nervous system diseases, in human medicine. Access to hyperbaric therapy has increased and ongoing research has furthered understanding of the mechanisms and potential therapeutic uses of HBOT.
Veterinary Data Synthesis – Several animal models have been utilized to examine the effects of HBOT; primarily rodents (mice, rats) and rabbits but also dogs, cats, and pigs. Data related to animal model research as it pertains to clinical application of HBOT is reviewed.
Conclusions – There is a substantial body of literature that has examined the adverse and beneficial effects of HBOT in animal models. As technology becomes more readily available to clinical practice and more clinical trials are performed to define its effectiveness, HBOT may be considered as an additional therapeutic option in many conditions including select problem wounds, spinal cord injury, and cerebral ischemic injury. Understanding the mechanisms by which HBOT exerts its effects will help guide research and use of the modality in clinical patients.read more
Citations
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Hyperbaric oxygen therapy
TL;DR: The clinical review criteria expressed below reflects how EmblemHealth determines whether certain services or supplies are medically necessary, and EmblemHealth expressly reserves the right to revise these conclusions as clinical information changes, and welcomes further relevant information.
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Hyperbaric oxygen for acute carbon monoxide poisoning
Journal ArticleDOI
Hyperbaric oxygen therapy for traumatic brain injury.
Lei Huang,Andre Obenaus +1 more
TL;DR: Hyperbaric oxygen therapy may serve as a promising neuroprotective strategy that when combined with other therapeutic targets for TBI patients which could improve long-term outcomes.
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Oxygenated kidney preservation techniques.
TL;DR: Evidence suggests that oxygenation is particularly beneficial in restoring cellular levels of adenosine triphosphate after kidneys have been subjected to warm or cold ischemic injury.
References
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Journal ArticleDOI
Hyperbaric Oxygen for Acute Carbon Monoxide Poisoning
Lindell K. Weaver,Ramona O. Hopkins,Karen J. Chan,Susan Churchill,C. Gregory Elliott,Terry P. Clemmer,James F. Orme,Frank Thomas,Alan H. Morris +8 more
TL;DR: Three hyperbaric-oxygen treatments within a 24-hour period appeared to reduce the risk of cognitive sequelae 6 weeks and 12 months after acute carbon monoxide poisoning.
Journal Article
Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration
TL;DR: These experiments demonstrate that: (1) A hypoxic tissue gradient is mandatory for wound-healing angiogenesis, (2) when the hypoxic gradient is destroyed capillary growth cases, and (3) inspired oxygen concentrations affect the rate and density of capillary Growth.
Journal Article
Hyperbaric oxygen therapy
TL;DR: The clinical review criteria expressed below reflects how EmblemHealth determines whether certain services or supplies are medically necessary, and EmblemHealth expressly reserves the right to revise these conclusions as clinical information changes, and welcomes further relevant information.
Journal ArticleDOI
Relationship of oxygen dose to angiogenesis induction in irradiated tissue.
TL;DR: It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.
Journal ArticleDOI
Oxygen toxicity in neonatal and adult animals of various species
TL;DR: In this paper, both infants and adults were exposed to 95+% O2 and showed significant changes in lung antioxidant enzyme activity (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPE), and GPE).