Hyperchloremic acidosis and nephrocalcinosis; the syndrome of pure lower nephron insufficiency.

doi:10.1001/ARCHINTE.1949.00220320025002

Journal ArticleDOI

Hyperchloremic acidosis and nephrocalcinosis; the syndrome of pure lower nephron insufficiency.

Ezra M. Greenspan

- 01 Mar 1949 -

JAMA Internal Medicine

- Vol. 83, Iss: 3, pp 271-291

TLDR

In this syndrome renal dysfunction was characterized by severe, intractable chronic hyperchloremic acidosis of months or years' duration, together with pronounced chronic polyuria, polydipsia, asthenia and either osteoporosis (adults) or "renal rickets" (children).

Abstract:

IN RECENT years the term "nephrocalcinosis" has been used to designate cases of bilateral generalized calcification within the renal parenchyma. In many instances little importance has been attached to the particular anatomic position of the multiple renal calcifications. However, several observers 1 called attention to a few rare cases of idiopathic nephrocalcinosis in which numerous submiliary, symmetric bilateral calcifications were confined to the renal pyramids. Special significance was attributed to the localization of the renal calcifications in these cases, since they were associated with a unique form of chronic renal failure. In this syndrome renal dysfunction was characterized by severe, intractable chronic hyperchloremic acidosis of months or years' duration, together with pronounced chronic polyuria, polydipsia, asthenia and either osteoporosis (adults) or "renal rickets" (children). Several therapeutic measures directed against this metabolic disorder resulted in prolonged symptomatic improvement. Lack of treatment predisposed to further deposition of calcium in the basement

Hyperchloremic acidosis and nephrocalcinosis; the syndrome of pure lower nephron insufficiency.

Citations

The pathogenesis of acute renal failure associated with traumatic and toxic injury; renal ischemia, nephrotoxic damage and the ischemic episode.

Active `juvenile' cirrhosis considered as part of a systemic disease and the effect of corticosteroid therapy

Sjögren's syndrome and renal tubular acidosis

Renal tubular acidosis with osteomalacia: Report of three cases

Renal hyperchloremic acidosis: Familial occurrence of nephrocalcinosis with hyperchloremia and low serum bicarbonate

References

Incipient myelomatosis or «essential« hyperglobulinemia with fibrinogenopenia — a new syndrome?

Sulphanilamide as a Specific Inhibitor of Carbonic Anhydrase

Studies of cryoglobulins; unusual purpura associated with the presence of a high concentration of cryoglobulin (cold precipitable serum globulin).

The nature of the renal tubular mechanism for acidifying the urine

Lower nephron nephrosis; the renal lesions of the crush syndrome, of burns, transfusions, and other conditions affecting the lower segments of the nephrons.

Related Papers (5)

Dehydration and acidosis with calcification at renal tubules

Idiopathic hyperchloraemic renal acidosis of infants (nephrocalcinosis infantum); observations on the site and nature of the lesion.

Osteomalacia and late rickets; the various etiologies met in the United States with emphasis on that resulting from a specific form of renal acidosis, the therapeutic indications for each etiological sub-group, and the relationship between osteomalacia and Milkman's syndrome.

Renal tubular acidosis with osteomalacia: Report of three cases

Hypercalcemia without hypercalcuria or hypophosphatemia, calcinosis and renal insufficiency; a syndrome following prolonged intake of milk and alkali.