Journal ArticleDOI
Sulphanilamide as a Specific Inhibitor of Carbonic Anhydrase
Thaddeus Mann,D. Keilin +1 more
TLDR
This enzyme plays an important part in accelerating the carbon dioxide output in the lungs; it appears also to promote the formation of hydrochloric acid by the parietal cells of gastric mucosa.Abstract:
CARBONIC anhydrase which catalyses the reversible reaction H2CO3 ⇄ CO2 + H2O is present in large concentrations in the red blood corpuscles and some cells of gastric mucosa of mammals. This enzyme plays an important part in accelerating the carbon dioxide output in the lungs; it appears also to promote the formation of hydrochloric acid by the parietal cells of gastric mucosa1.read more
Citations
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Journal ArticleDOI
Recent Advances in Zinc Enzymology
TL;DR: Zinc enzymology is, compared to some other current areas of metallobiochemistry, a maturing field, but in addition to further developments of structure-function relationships it has also provided a number of surprising new results and ideas in the last few years.
PatentDOI
Carbonic anhydrase inhibitors
Peter Ebbesen,Claudlu T. Supuran,Andrea Scozzafava,Erik Olai Pettersen,Kaye Williams,L.J. Dubois,Philippe Lambin +6 more
TL;DR: A carbonic anhydrase IX (CA IX) inhibitor is a compound of general formula: R-NH-CX-NH-(CH 2 ) n -Ar-Q-SO 2 -NH 2 or a pharmaceutically acceptable salt, derivative or prodrug thereof.
Journal ArticleDOI
Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors
Pengju Jiang,Zijian Guo +1 more
TL;DR: In this article, the progress made in the past decade or so, focusing on sensor design strategy based on molecular structure and fluorescent mechanism is reviewed, and the results show that fluorescent imaging has proven to be the most suitable technique for its in vivo monitoring.
Journal ArticleDOI
Structure and function of carbonic anhydrases
TL;DR: Structural-based drug design campaigns allowed the discovery of highly isoform selective CA inhibitors (CAIs), which may lead to a new generation of drugs targeting these widespread enzymes, and the use of CAs in CO2 capture processes for mitigating the global temperature rise has also been investigated more recently.
Journal ArticleDOI
Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein–Ligand Binding
Vijay M. Krishnamurthy,George K. Kaufman,Adam R. Urbach,Irina Gitlin,Katherine L. Gudiksen,Douglas B. Weibel,George M. Whitesides +6 more
TL;DR: Carbonic anhydrase is a protein that is especially well-suited to serve as a model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of inhibitor design, and medicinal chemistry.
References
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Journal ArticleDOI
Gastric carbonic anhydrase.
TL;DR: Davenport (1939) demonstrated that carbonic anhydrase is present in high concentration in the parietal cells and in lower concentrations in the cells of the surface epithelium of the gastric mucosa of cats and rats.
Journal ArticleDOI
Mechanism of Nitrogen Excitation in the Night Sky
J. Cabannes,Rose Aynard +1 more
TL;DR: In this article, the authors considered the three-body collision and showed that in such a collision the energy made available is D = 7·05 volts and the corresponding quantum number υ2 is at most equal to 5.
Journal ArticleDOI
Acidosis Associated with the Administration of Para-amino-benzene-sulfonamide (Prontylin)
TL;DR: Two cases of clinical acidosis due to the administration of Prontylin (Para-amino-benzene-sulfonamide) in large doses are reported.