Journal ArticleDOI
Hyperreactive malarious splenomegaly (tropical splenomegaly syndrome)
TLDR
Gross overproduction of IgM antibodies leads to the formation of high molecular weight immune complexes, persistent gross splenomegaly recurrent episodes of profound anaemia and increased susceptibility to infections.About:
This article is published in Parasitology Today.The article was published on 1986-01-01. It has received 64 citations till now. The article focuses on the topics: Tropical splenomegaly syndrome & Splenic disease.read more
Citations
More filters
Journal ArticleDOI
Anaemia and malaria
TL;DR: Prevention of malaria by vector control, deployment of insecticide-treated bed nets, prompt and accurate diagnosis of illness and appropriate use of effective anti-malarial drugs substantially reduces the burden of anaemia in tropical countries.
Journal ArticleDOI
Asymptomatic malaria infections — Do they matter?
TL;DR: Research on hookworms, using recently developed animal models and epidemiological projects linking immuno- logical assays with resistance and worm loss in the field, and a concerted effort to apply the tools of modern experimental medicine will help to elucidate aspects of hookworm biol- ogy which have eluded experimenters in the past.
Journal ArticleDOI
The role of low level Plasmodium falciparum parasitaemia in anaemia among infants living in an area of intense and perennial transmission
Andrew Y Kitua,Thomas J. Smith,P. L. Alonso,Honoraty Urassa,Honorati Masanja,J. Kimario,Marcel Tanner +6 more
TL;DR: It is suggested that interventions which lower parasite densities in areas of intense transmission reduce the development of severe malarial anaemia and thus malaria‐related mortality and morbidity in infants.
Journal ArticleDOI
Ethnic differences in the prevalence of splenomegaly and malaria in The Gambia
Brian Greenwood,F. Groenendaal,A.K. Bradley,A.M. Greenwood,F.C. Shenton,S. Tulloch,Richard J. Hayes +6 more
TL;DR: Among young children splenomegaly and malaria were less prevalent in Mandinkas than in Wollofs or Fulas, suggesting that some genetic or environmental factors protect Mandinka children from this infection.
Journal ArticleDOI
Molecular basis for evasion of host immunity and pathogenesis in malaria
TL;DR: The article relates the ability of the malaria parasite Plasmodium falciparum to avoid a protective immune response, and to induce pathological changes, to the properties of specific parasite molecules.
References
More filters
Journal ArticleDOI
` Non-tropical idiopathic splenomegaly ' (`primary hypersplenism'): a review of ten cases and their relationship to malignant lymphomas.
TL;DR: The spleen was grossly enlarged in all 10 patients and the liver was palpable in seven but there was no evidence of cirrhosis or portal hypertension.
Journal ArticleDOI
An investigation of tropical splenomegaly at mulago hospital, kampala, uganda.
P. D. Marsden,M. S. R. Hutt,N. E. Wilks,A. Voller,V. Blackman,K. K. Shah,D. H. Connor,P. J. S. Hamilton,J. G. Banwell,H. F. Lunn +9 more
TL;DR: This work is indebted to Dr. H. El Ghoroury, Institute of Hygiene, Alexandria, for helpful advice and valuable criticism.
Journal ArticleDOI
Malaria and splenomegaly
A. Bryceson,Y.M. Fakunle,A.F. Fleming,G. Crane,M.S.R. Hutt,K.M. de Cock,Brian Greenwood,P.D. Marsden,P.H. Rees +8 more
Journal ArticleDOI
Reduction of Suppressor T Lymphocytes in the Tropical Splenomegaly Syndrome
Stephen L. Hoffman,Willy F. Piessens,Sutanti Ratiwayanto,P. R. Hussein,Liliana Kurniawan,Patricia W. Piessens,James R. Campbell,Harijani A. Marwoto +7 more
TL;DR: It is suggested that overproduction of immunoglobulins in patients with tropical splenomegaly syndrome is caused by an imbalance in the normal ratio of helper: suppressor T cells that regulate B-lymphocyte function, and that this imbalance is due to a decrease in suppressionor T lymphocytes.