Journal ArticleDOI
Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries.
TLDR
It is concluded that transmural myocardial infarction in the absence of significant coronary atherosclerosis is a not uncommon finding in a population of patients who had died from hypertrophic cardiomyopathy.Abstract:
Clinical and morphologic features of transmural myocardial infarction (associated with insignificant or absent atherosclerosis of the extramural coronary arteries) are described in seven patients with hypertrophic cardiomyopathy. Marked chronic congestive heart failure associated with supraventricular arrhythmias occurred in six of the seven patients, each of whom had no or mild left ventricular outflow tract obstruction under basal conditions. No patient had typical angina pectoris, and only one patient had clinically evident acute myocardial infarction. Infarction may have caused cardiac arrest in one other patient, but was "silent" in the remaining five patients. At necropsy, six of the seven patients had extensive myocardial scarring involving the ventricular septum, left ventricular free wall and one or both left ventricular papillary muscles; in four patients portions of the right ventricular wall were also scarred. Six patients had dilated ventricular cavities, including two who were known to have nondilated ventricular cavities earlier in their clinical course. It is concluded that transmural myocardial infarction in the absence of significant coronary atherosclerosis is a not uncommon finding (prevalence rate 15 percent) in a population of patients who had died from hypertrophic cardiomyopathy. Although transmural infarction is possibly a secondary event, it more likely contributes causally to the clinical deterioration of some patients with hypertrophic cardiomyopathy, leading to ventricular dilatation and progressive fatal cardiac failure.read more
Citations
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Journal ArticleDOI
Hypertrophic cardiomyopathy: A Systematic review
TL;DR: An appreciation that HCM, although an important cause of death and disability at all ages, does not invariably convey ominous prognosis and is compatible with normal longevity should dictate a large measure of reassurance for many patients.
Book
Coronary Microvascular Dysfunction
Paolo G. Camici,Filippo Crea +1 more
TL;DR: This review discusses the pathogenesis and management of coronary microvascular dysfunction and factors to consider in clinical management are the cause of the dysfunction and whether it is iatrogenic, whether obstructive coronary artery disease is present, and whether myocardial disease ispresent.
Journal ArticleDOI
American College of Cardiology/European Society of Cardiology Clinical Expert Consensus Document on Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines
Barry J. Maron,William J. McKenna,Gordon K. Danielson,Lukas Kappenberger,Horst J. Kuhn,Christine E. Seidman,Pravin M. Shah,William H. Spencer,Paolo Spirito,Folkert J. Ten Cate,E. Douglas Wigle,Robert A. Vogel,Jonathan Abrams,Eric R. Bates,Bruce R. Brodie,Peter G. Danias,Gabriel Gregoratos,Mark A. Hlatky,Judith S. Hochman,Sanjiv Kaul,Robert C. Lichtenberg,Jonathan R. Lindner,Robert A. O'Rourke,Gerald M. Pohost,Richard S. Schofield,Cynthia M. Tracy,William L. Winters,Werner Klein,Silvia G. Priori,Angeles Alonso-Garcia,Carina Blomström-Lundqvist,Guy De Backer,Jaap W. Deckers,Markus Flather,Jaromír Hradec,Ali Oto,Alexander Parkhomenko,Sigmund Silber,Adam Torbicki +38 more
TL;DR: In this paper, the authors present a general approach for the natural history and clinical course of clinical diagnostics in the context of vascular flow outflow and genetic and molecular diagnostics.
Journal ArticleDOI
The management of hypertrophic cardiomyopathy.
TL;DR: Hypertrophic cardiomyopathy is a complex cardiac disease with unique pathophysiologic characteristics and a great diversity of morphologic, functional, and clinical features as discussed by the authors, and the heterogeneity of the disease is accentuated by the fact that it afflicts patients of all ages.
Journal ArticleDOI
Hypertrophic cardiomyopathy. Interrelations of clinical manifestations, pathophysiology, and therapy (1).
TL;DR: Seconde partie d'une revue: interrelations entre mecanismes physiopathologiques et manifestations cliniques ; traitement medical; traitement chirurgical.
References
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Journal ArticleDOI
Idiopathic Hypertrophic Subaortic Stenosis: I. A Description of the Disease Based Upon an Analysis of 64 Patients
TL;DR: The finding of a murmur before the age of 1 year in 9 of the 64 patients, and the reports of IHSS in a stillborn baby and in several infants, as well as the association of IhSS with congenital cardiac malformations, all support the concept that the disease may, at least in some instances, be congenital.
Journal ArticleDOI
Coronary arterial spasm in Prinzmetal angina. Documentation by coronary arteriography.
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Journal ArticleDOI
Asymmetric Septal Hypertrophy: Echocardiographic Identification of the Pathognomonic Anatomic Abnormality of IHSS
TL;DR: The findings indicate that the detection of ASH identifies the pathognomonic anatomic abnormality in IHSS and includes a wider spectrum of patients (i.e. those without obstruction as well as clinically normal family members of patients with IhSS), and suggests that a more appropriate term for this disease entity is asymmetric septal hypertrophy or ASH.
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