Journal ArticleDOI
IgE in allergy and asthma today
Hannah J. Gould,Brian J. Sutton +1 more
TLDR
Recent progress in uncovering the structures of IgE proteins and their complexes is reviewed, and the information that has emerged suggests new therapeutic directions for combating allergic disease.Abstract:
The spreading epidemic of allergies and asthma has heightened interest in IgE, the central player in the allergic response. The activity of IgE is associated with a network of proteins; prominent among these are its two principal receptors, FcepsilonRI (high-affinity Fc receptor for IgE) and CD23, as well as galectin-3 and several co-receptors for CD23, notably CD21 and various integrins. Here, we review recent progress in uncovering the structures of these proteins and their complexes, and in our understanding of how IgE exerts its effects and how its expression is regulated. The information that has emerged suggests new therapeutic directions for combating allergic disease.read more
Citations
More filters
Journal ArticleDOI
The development of allergic inflammation
TL;DR: It is important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reaction.
Journal ArticleDOI
IgE and mast cells in allergic disease
Stephen J. Galli,Mindy Tsai +1 more
TL;DR: Findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders are discussed.
Journal ArticleDOI
The safety and side effects of monoclonal antibodies
TL;DR: Some of the adverse effects encountered with mAb therapies are reviewed, and advances in preclinical testing and antibody technology aimed at minimizing the risk of these events are discussed.
Journal ArticleDOI
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.
TL;DR: Understanding the interaction of the microbiota with pathogens and the immune system will provide critical insight into the pathogenesis of disease and the development of strategies to prevent and treat inflammatory disease.
Journal ArticleDOI
Treatment strategies for allergy and asthma
TL;DR: There is now considerable optimism with regards to tackling the allergy epidemic in light of improvements in systemic and mucosal allergen-specific immunotherapy, the identification of key cytokines and their receptors that drive T-helper-2-cell polarization, a clearer understanding of the pathways of leukocyte recruitment and the signalling pathways that are involved in cell activation and mediator secretion, and new approaches to vaccine development.
References
More filters
Journal ArticleDOI
Competence and competition : the challenge of becoming a long-lived plasma cell
Andreas Radbruch,Gwendolin Muehlinghaus,Elke Luger,Ayako Inamine,Kenneth G. C. Smith,Thomas Dörner,Falk Hiepe +6 more
TL;DR: Studies of the biology of plasma cells reveal a mechanism of intriguing simplicity and elegance that focuses memory provided by plasma cells on recently encountered pathogens while minimizing the 'fading' of memory for pathogens encountered in the distant past.
Journal ArticleDOI
The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology.
TL;DR: The high affinity receptor for immunoglobulin E (designated Fc epsilon RI) is the member of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific IgEs with cellular immunologic effector functions as mentioned in this paper.
Journal ArticleDOI
Oral tolerance: immune mechanisms and treatment of autoimmune diseases
TL;DR: Orally administered autoantigens suppress many experimental autoimmune diseases, as discussed here by Howard Weiner.
Journal ArticleDOI
Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
Merci Kusel,Nicholas de Klerk,Tatiana Kebadze,Vaike Vohma,Patrick G. Holt,Sebastian L. Johnston,Peter D. Sly +6 more
TL;DR: Data suggest viral infections interact with atopy in infancy to promote later asthma, and protection of “high-risk” children against the effects of severe respiratory infections during infancy may represent an effective strategy for primary asthma prevention.
Journal ArticleDOI
The biology of IGE and the basis of allergic disease.
Hannah J. Gould,Brian J. Sutton,Andrew J. Beavil,Rebecca L. Beavil,Natalie McCloskey,Heather A. Coker,David J. Fear,Lyn Smurthwaite +7 more
TL;DR: There is now compelling evidence that the microenvironment of mucosal tissues of allergic disease favors class switching to IgE; and the exceptionally high affinity of IgE for FcepsilonRI can now be interpreted in terms of the recently determined crystal structures of IgG-FcgammaR complexes.