Journal ArticleDOI
Immune-complex glomerulopathy in patients treated with captopril
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Renal biopsies were performed on 13 patients treated with captopril and findings indicated an early stage of membranous glomerulopathy (MGP), which may be associated with the development of immune-complex glomerULopathy.About:
This article is published in The Lancet.The article was published on 1980-06-07. It has received 293 citations till now. The article focuses on the topics: Glomerulopathy & Nephrotic syndrome.read more
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Drug Prescribing in Renal Failure: Dosing Guidelines for Adults
William M. Bennett,George R. Aronoff,Gail Morrison,Thomas A. Golper,Joseph P. Pulliam,Marsha Wolfson,Irwin Singer +6 more
TL;DR: The data base for rational guidelines to safe, efficacious drug prescribing in adults with renal insufficiency is presented in tabular form in this paper, where recommendations are based on pharmacokinetic variables in normal subjects.
Journal ArticleDOI
Captopril: a preliminary review of its pharmacological properties and therapeutic efficacy.
TL;DR: Captopril must be considered an exciting addition to the therapeutic armamentarium; it, and pharmacologically related compounds of the future, will continue to generate much interest as their final place in therapy becomes better defined through additional well designed studies and wider clinical experience.
Journal ArticleDOI
High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood
TL;DR: To the authors's knowledge the effect of high dose therapy with cyclophosphamide during childhood on adult testicular reproductive and endocrine function has not been established.
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Risk factors for ovarian failure in patients with systemic lupus erythematosus receiving cyclophosphamide therapy
TL;DR: In the population of female SLE patients, CYC-induced ovarian toxicity is a significant problem, particularly in patients above the age of 40, and the age at the start of CYC therapy and the cumulative dose are the major determinants for the development of this complication.
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Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in Man
Haralambos Gavras,Hans R. Brunner,Gustave A. Turini,Glenn R. Kershaw,Charles P. Tifft,Sergio Cuttelod,Irene Gavras,Robert A. Vukovich,Doris N. McKinstry +8 more
TL;DR: SQ 14225 is a promising new antihypertensive agent, effective in patients refractory to traditional medical therapy, and the exact mechanisms contributing to the blood-pressure-lowering effect of this agent remain unclear.
Journal ArticleDOI
IMMUNOLOGY OF DNA. III. CRITHIDIA LUCILIAE, A SIMPLE SUBSTRATE FOR THE DETERMINATION OF ANTI‐dsDNA WITH THE IMMUNOFLUORESCENCE TECHNIQUE*
TL;DR: A very good correlation between this test and the Farr assay for the demonstration of antibodies to double-stranded DNA is demonstrated.
Journal ArticleDOI
Clinical experience with blockade of the renin-angiotensin-aldosterone system by an oral converting-enzyme inhibitor (SQ 14,225, captopril) in hypertensive patients.
David B. Case,Steven A. Atlas,John H. Laragh,Jean E. Sealey,Patricia A. Sullivan,Doris N. McKinstry +5 more
TL;DR: Examination of the renin-lowering effect of β-adrenergic blockade in patients with essential and malignant hypertension found that propranolol in low to moderate doses lowers blood pressure in high an normal renin forms of hypertension but does not significantly lowerBlood pressure in low renin hypertensive pateints.
Journal ArticleDOI
Captopril in the treatment of clinical hypertension and cardiac failure
Journal ArticleDOI
Converting enzyme inhibition with an orally active compound in hypertensive man.
E L Bravo,R C Tarazi +1 more
TL;DR: The present study indicates that this agent may be a practical therapeutic adjunct in the treatment of certain subsets of the human hypertensive population, and the lack of serious interference with cardiovascular and humoral homeostasis adds to its attractiveness as a therapeutic agent.