Journal ArticleDOI
Immune complexes in hepatitis
June D. Almeida,A. P. Waterson +1 more
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TLDR
The range of immunological response illustrated by three cases (no antibody production, antigen excess, and formation, in the fatal case, of anaphylactogenic immune complexes) suggests certain similarities between Au-SH antigen hepatitis and serum sickness, a condition where the severity seems to depend on the balance between antigen and antibody.About:
This article is published in The Lancet.The article was published on 1969-11-08. It has received 290 citations till now. The article focuses on the topics: Antigen & Blocking antibody.read more
Citations
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Journal ArticleDOI
Cellular immunity and hepatitis-associated, Australia antigen liver disease.
TL;DR: It is suggested that the competence of the cell-mediated (T-lymphocyte-dependent) immune system would decide whether the infection is self-limited or persists with varying degrees of liver damage.
Book ChapterDOI
The Biology and Detection of Immune Complexes
TL;DR: This chapter describes the interaction of immune complexes (ICs) with complement and with the cells of the immune system, thereby making it possible to identify the antigens involved in immune processes of a great many diseases, including those of unknown etiology.
Journal ArticleDOI
Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen QUANTITATION BY BINDING TO RADIOLABELED Clq
TL;DR: The utility of the radiolabeled C1q binding assay for the evaluation of immune complex diseases in human pathology is suggested.
Journal ArticleDOI
New antigen-antibody system in australia-antigen-positive hepatitis
TL;DR: It is suggested that, in an attack of serum hepatitis, Au-Ag antibody develops but is subsequently cleared; antibody against the inner Dane component, however, persists.
Journal ArticleDOI
The pathogenesis of arthritis associated with viral hepatitis. Complement-component studies.
TL;DR: The correlation of joint and skin symptoms with hepatitis-associated antigen and depressed levels of complement activity in the acute state suggests that this serum-sickness-like syndrome in patients with acute viral hepatitis is a virus-associated syndrome.
References
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Journal ArticleDOI
A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis.
TL;DR: This work has reported the presence of an isoantigen of human sera, rare or absent in normal U. S. and northern European populations but relatively common in patients with leukemia, and its role in the development of leukemia is unclear.
Journal ArticleDOI
The carrier state in viral hepatitis.
Joseph Stokes,J. Edward Berk,Leonard L. Malamut,Miles E. Drake,Jeremiah A. Barondess,Winslow J. Bashe,Irving J. Wolman,John D. Farquhar,B. Bevan,R. J. Drummond,W. d'A. Maycock,Richard B. Capps,Alfred M. Bennett +12 more
TL;DR: VIRAL HEPATITIS B Although considerable presumptive evidence concerning carriers of hepatitis virus B (serum hepatitis virus) can be seen in retrospect to have accumulated since 1920, it is suggested that a considerable proportion, probably 0.2 to 0.5%, of the general population carry this virus.
Journal ArticleDOI
Homologous serum jaundice
TL;DR: This interpretation fails to explain how homologous serum jaundice arose in the first place, and it leaves only a vague idea of what might happen were an individual who has just recovered from natural hepatitis used as a blood donor.