Journal ArticleDOI
Immunocytochemical analysis of estrogen receptors in human breast carcinomas. Evaluation of 130 cases and review of the literature regarding concordance with biochemical assay and clinical relevance.
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TLDR
The evaluation of receptor heterogeneity, made possible by the ER-ICA, may enhance the ability to discriminate ER-positive tumors with a relatively high risk of recurrence.Abstract:
• An estrogen receptor–immunocytochemical assay (ER-ICA) was performed on frozen sections of 130 samples of human breast carcinoma. A standard dextran-coated charcoal assay (DCCA) was performed on the same samples. Concordance of results between the tests was 91%. The sensitivity and specificity of the ER-ICA, compared with the DCCA, were 92% and 89%, respectively. We describe the ER-ICA technique and review the literature regarding the use of the ER-ICA in evaluating breast cancer with respect to the agreement of results with the DCCA, the nature of discordant results, the ability to predict the clinical response to hormone therapy, and the ability to predict disease-free survival. The combined experience of many studies has shown that the ER-ICA is a highly specific and sensitive method for measuring the level of ERs in breast tumors with a high level of agreement with the DCCA. Early experience has suggested that the ER-ICA can predict the response to hormone therapy and disease-free survival, as well as or better than the DCCA. The evaluation of receptor heterogeneity, made possible by the ER-ICA, may enhance our ability to discriminate ER-positive tumors with a relatively high risk of recurrence. (Arch Surg. 1990;125:107-113)read more
Citations
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Journal ArticleDOI
Tissue microarrays for high-throughput molecular profiling of tumor specimens
Juha Kononen,Lukas Bubendorf,Anne Kallioniemi,Maarit Bärlund,Peter Schraml,S Leighton,Joachim Torhorst,Michael J. Mihatsch,Guido Sauter,Olli Kallioniemi +9 more
TL;DR: In this paper, an array-based high-throughput technique that facilitates gene expression and copy number surveys of very large numbers of tumors is presented. But, it is limited to a single tumor tissue microarray.
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Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer
TL;DR: IHC is superior to the LBA for assessing ER status in primary breast cancer because it is easier, safer, and less expensive, and has an equivalent or better ability to predict response to adjuvant endocrine therapy.
Journal ArticleDOI
Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999.
Patrick L. Fitzgibbons,David L. Page,Donald L. Weaver,Ann D. Thor,Allred Dc,Gary M. Clark,Stephen G. Ruby,O'Malley F,Simpson Jf,James L. Connolly,Daniel F. Hayes,Stephen B. Edge,Lichter A,Stuart J. Schnitt +13 more
TL;DR: This report constitutes a detailed outline of the findings and recommendations of the consensus conference group, organized according to structural guidelines as defined.
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Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients.
TL;DR: The higher relative mortality risks identified among ER-/PR- patients with small or low-grade tumors raise the question of whether there may be a beneficial role for adjuvant chemotherapy in this population of women.
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Steroid hormone receptors in breast cancer management.
TL;DR: ER and PR status are important biomarkers that help physicians individualize therapy and appear to have important structural and functional differences that may be important for tissue and promoter- specific regulation of gene expression.
References
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Journal Article
Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies.
TL;DR: A monoclonal antibody against estrogen receptor (H222 Sp gamma) was used on cryostat sections of freshly frozen breast tumors with a peroxidase-antiperoxidases immunoperoxid enzyme technique to study sensitivity and specificity of estrogen receptor in patients treated with hormonal therapy.
Journal ArticleDOI
The value of estrogen and progesterone receptors in the treatment of breast cancer
TL;DR: Preliminary analysis suggests that the presence of PgR may be a better marker of tumor hormone dependence than quantitative ER, which is an important independent prognostic indicator of higher rate of recurrence and shorter survival.
Book ChapterDOI
Molecular Biology of Human T-Lymphotropic Retroviruses
Flossie Wong-Staal,Lee Ratner,George M. Shaw,Beatrice H. Hahn,Mary E. Harper,Genoveffa Franchini,Robert C. Gallo +6 more
TL;DR: HTLV-III frequently infects the brain of acquired immunodeficiency syndrome patients who suffer from central nervous system disorders and poses the problem of crossing the blood-brain barrier in therapy strategies to eradicate the virus, which provides a basis for new classification of retroviruses.
Journal ArticleDOI
Steroid receptors and other prognostic factors in primary breast cancer.
Gary M. Clark,William L. McGuire +1 more
TL;DR: A review and update of published studies on prognostic factors support the following conclusions: the number of axillary lymph nodes involved with tumor remains the most important prognostic factor for women with primary breast cancer.