Journal ArticleDOI
Immunoglobulin levels in the Kaiapit and upper Watut areas of New Guinea: with special reference to the tropical splenomegaly syndrome
TLDR
The change in the pattern of immunoglobulin levels in association with splenomegaly occurred between the ages of 6 and 20 years, indicating that the transition from simple malarious splenomesgaly to tropical splenomgaly syndrome probably occurs at this age.Abstract:
Serum concentrations of IgA, IgG and IgM were estimated for 2,000 inhabitants of 2 malarious areas of New Guinea—Kaiapit, where spleen rates are high in children but splenomegaly occurs infrequently in adults and is never gross, and the Upper Watut Valley, where the tropical splenomegaly syndrome is particularly common, and 80% of adults and children have palpable spleens. Kaiapit adults had significantly higher IgM levels than children: IgM levels tended to increase throughout life, were higher in women than in men and in adults with splenomegaly. IgG and IgA levels showed no significant relation to increasing age above 10 years, to sex or to the presence or absence of splenomegaly. The youngest Watut children had higher IgM levels than Kaiapit subjects. IgM concentrations rose more rapidly with age, particularly in the first 20 years of life, so that the mean Watut adult level was more than twice that of Kaiapit adults. In Watut children splenomegaly was associated with significantly higher levels of all 3 immunoglobulin fractions, whereas adults with splenomegaly showed markedly higher levels of IgM, but significantly lower IgA concentrations than did subjects with impalpable spleens. The change in the pattern of immunoglobulin levels in association with splenomegaly occurred between the ages of 6 and 20 years, indicating that the transition from simple malarious splenomegaly to tropical splenomegaly syndrome probably occurs at this age. Subjects living near the valley floor had higher spleen rates than those living in high villages; IgM concentrations were also affected by altitude. The reason for this remains obscure, but it is suggested that both observations may be related to differences in intensity of operation of the factors responsible for the development of the tropical splenomegaly syndrome.read more
Citations
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Journal ArticleDOI
Possible role of a B-cell mitogen in hypergammaglobulinaemia in malaria and trypanosomiasis.
TL;DR: Serum-immunoglobulins, especially IgM, increase considerably in patients with malaria and trypanosomiasis, and this immunoglobulin contains not only specific anti-parasite antibodies but also antibodies reacting with other non-Parasite antigenic determinants, including those of host tissue.
Journal ArticleDOI
Hyperreactive malarious splenomegaly (tropical splenomegaly syndrome)
TL;DR: Gross overproduction of IgM antibodies leads to the formation of high molecular weight immune complexes, persistent gross splenomegaly recurrent episodes of profound anaemia and increased susceptibility to infections.
Journal ArticleDOI
The hyper-reactive malarial splenomegaly: a systematic review of the literature.
TL;DR: For patients not re-exposed to endemic areas, a short course of treatment is sufficient, showing that eradicating the infection is sufficient to cure HMS.
Journal ArticleDOI
Tropical splenomegaly syndrome in New Guinea I. Natural history
G.G. Crane,J V Wells,P Hudson +2 more
TL;DR: The natural history of the tropical splenomegaly syndrome is that of a progressive disease with a high mortality in the fully developed case, largely related to the occurrence of episodes of acute haemolysis.
Journal ArticleDOI
Malarial antibodies in tropical splenomegaly syndrome in Papua New Guinea.
TL;DR: It is concluded that there is no evidence from this study to incriminate any one species of malaria parasite in the production of tropical splenomegaly syndrome.
References
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IMMUNOGLOBULIN LEVELS IN ETHIOPIAN PRESCHOOL CHILDREN WITH SPECIAL REFERENCE TO HIGH CONCENTRATIONS OF IMMUNOGLOBULIN E (IgND)
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Malarial antibodies and autoantibodies to heart and other tissues in the immigrant and indigenous peoples of uganda
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Journal ArticleDOI
Liver in Felty's Syndrome
TL;DR: Liver function and histology, together with the haematological changes, were investigated in 12 patients with Felty's syndrome; six of them were anaemic, and two patients had increased haemolysis associated with red cell sequestration by the enlarged spleens.
Journal ArticleDOI
` Non-tropical idiopathic splenomegaly ' (`primary hypersplenism'): a review of ten cases and their relationship to malignant lymphomas.
TL;DR: The spleen was grossly enlarged in all 10 patients and the liver was palpable in seven but there was no evidence of cirrhosis or portal hypertension.