Journal ArticleDOI
Impact of bowel dysfunction on quality of life after sphincter‐preserving resection for rectal cancer
TLDR
The aim of this study was to examine the extent of bowel dysfunction and impact on health‐related QoL after curative sphincter‐preserving resection for rectal cancer.Abstract:
Background
Bowel dysfunction after sphincter-preserving surgery for rectal cancer is a common complication, with the potential to affect quality of life (QoL) strongly. The aim of this study was to examine the extent of bowel dysfunction and impact on health-related QoL after curative sphincter-preserving resection for rectal cancer.
Methods
QoL was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire, and bowel function using a validated questionnaire, including the recently developed low anterior resection syndrome (LARS) score. Assessments were carried out at the time of diagnosis, and at 3 and 12 months after surgery.
Results
A total of 260 patients were included in the study. At 3 months, 58·0 per cent of patients had a LARS score of 30 or more (major LARS), which declined to 45·9 per cent at 12 months (P < 0·001). The risk of major LARS was significantly increased in patients who received neoadjuvant therapy (odds ratio 2·41, 95 per cent confidence interval 1·00 to 5·83), and after total versus partial mesorectal excision (odds ratio 2·81, 1·35 to 5·88). Global health status was closely associated with LARS, and significant differences in global health status, functional and symptom scales of QoL were found between patients without LARS and those with major LARS.
Conclusion
Bowel dysfunction is a major problem with an immense impact on QoL following sphincter-preserving resection. The risk of major LARS was significantly increased after neoadjuvant therapy and total mesorectal excision.read more
Citations
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Journal ArticleDOI
Cancer treatment and survivorship statistics, 2016.
Kimberly D. Miller,Rebecca L. Siegel,Chun Chieh Lin,Angela B. Mariotto,Joan L. Kramer,Julia H. Rowland,Kevin Stein,Rick Alteri,Ahmedin Jemal +8 more
TL;DR: The number of cancer survivors continues to increase because of both advances in early detection and treatment and the aging and growth of the population and for the public health community to better serve these survivors, the American Cancer Society and the National Cancer Institute collaborate to estimate the number of current and future cancer survivors.
Journal ArticleDOI
Cancer treatment and survivorship statistics, 2019
Kimberly D. Miller,Leticia Nogueira,Angela B. Mariotto,Julia H. Rowland,K. Robin Yabroff,Catherine M. Alfano,Ahmedin Jemal,Joan L. Kramer,Rebecca L. Siegel +8 more
TL;DR: Estimating cancer prevalence in the United States using incidence and survival data from the Surveillance, Epidemiology, and End Results cancer registries; vital statistics from the Centers for Disease Control and Prevention's National Center for Health Statistics; and population projections from the US Census Bureau is presented.
Journal ArticleDOI
Cancer treatment and survivorship statistics, 2022
Kimberly D. Miller,Leticia Nogueira,Theresa P Devasia,Angela B. Mariotto,K. Robin Yabroff,Ahmedin Jemal,Joan L. Kramer,Rebecca L. Siegel +7 more
TL;DR: Estimation of cancer prevalence in the United States using incidence and survival data from the Surveillance, Epidemiology, and End Results cancer registries, vital statistics from the Centers for Disease Control and Prevention’s National Center for Health Statistics, and population projections from the US Census Bureau finds that more than 18 million Americans with a history of cancer were alive on January 1, 2022.
Journal ArticleDOI
American Cancer Society Colorectal Cancer Survivorship Care Guidelines
Khaled El-Shami,Kevin C. Oeffinger,Nicole L. Erb,Anne Willis,Jennifer K. Bretsch,Mandi Pratt-Chapman,Rachel S. Cannady,Sandra L. Wong,Johnie Rose,April Barbour,Kevin Stein,Katherine Sharpe,Durado Brooks,Rebecca Cowens-Alvarado +13 more
TL;DR: In this paper, the authors present guidelines to assist primary care clinicians in delivering risk-based health care for colorectal cancer survivors who have completed active therapy, including communication and coordination of care between the treating oncologist and the primary care clinician to effectively manage the long-term care of CRC survivors.
Journal ArticleDOI
Bowel Function 14 Years After Preoperative Short-Course Radiotherapy and Total Mesorectal Excision for Rectal Cancer: Report of a Multicenter Randomized Trial
Tina Yen-Ting Chen,Lisette M. Wiltink,Remi A. Nout,Elma Meershoek-Klein Kranenbarg,Søren Laurberg,Corrie A.M. Marijnen,Cornelis J.H. van de Velde +6 more
TL;DR: A considerable proportion of nonstoma patients endured major LARS years after total mesorectal excision with or without preoperative short-course radiotherapy for rectal cancer, and the association of bowel dysfunction with health-related quality of life (HRQL).
References
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Journal ArticleDOI
The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology
Neil K. Aaronson,Sam H Ahmedzai,Bengt Bergman,Monika Bullinger,Ann Cull,Nicole Duez,Antonio Filiberti,Henning Flechtner,Stewart B. Fleishman,Johanna C. J. M. de Haes,Stein Kaasa,M. Klee,David Osoba,Darius Razavi,Peter B. Rofe,Simon Schraub,Kommer C. A. Sneeuw,Marianne Sullivan,Fumikazu Takeda +18 more
TL;DR: The reliability and validity of the EORTC QLQ-C30 questionnaire were highly consistent across the three language-cultural groups studied: patients from English-speaking countries, Northern Europe, and Southern Europe.
Journal ArticleDOI
Interpreting the significance of changes in health-related quality-of-life scores.
TL;DR: The significance of changes in QLQ-C30 scores can be interpreted in terms of small, moderate, or large changes in quality of life as reported by patients in the SSQ.
EORTC QLQ-C30 Scoring Manual
Peter Fayers,Neil K. Aaronson,Neil K. Aaronson,Kristin Bjordal,Kristin Bjordal,Kristin Bjordal,Mogens Groenvold,Desmond Curran,Andrew Bottomley +8 more
Journal ArticleDOI
The TME Trial After a Median Follow-Up of 6 Years: Increased Local Control but No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma
Koen C.M.J. Peeters,Corrie A.M. Marijnen,Iris D. Nagtegaal,Elma Meershoek – Klein Kranenbarg,Hein Putter,Theo Wiggers,Harm J. T. Rutten,Lars Påhlman,Bengt Glimelius,Jan Willem H. Leer,Cornelis J.H. van de Velde +10 more
TL;DR: There is a persisting overall effect of preoperative short-term radiotherapy on local control in patients with clinically resectable rectal cancer, however, there is no effect on overall survival.