Journal ArticleDOI
Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats
Reads0
Chats0
TLDR
A model of uteroplacental insufficiency, a common cause of intrauterine growth retardation, in the rat is developed and it is shown that impaired ATP synthesis in muscle compromises energy-dependent GLUT4 recruitment to the cell surface, glucose transport, and glycogen synthesis, which contribute to insulin resistance and hyperglycemia of type 2 diabetes.Abstract:
Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in later life. We have developed a model of uteroplacental insufficiency, a common cause of intrauterine...read more
Citations
More filters
Journal ArticleDOI
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
TL;DR: This review focuses on those experimental studies that have investigated the critical windows during which perturbations of the intrauterine environment have major effects, the nature of the epigenetic, structural, and functional adaptive responses which result in a permanent programming of cardiovascular and metabolic function, and the role of the interaction between the pre- and postnatal environment in determining final health outcomes.
Journal ArticleDOI
The developmental origins of the metabolic syndrome
Peter D. Gluckman,Mark A. Hanson +1 more
TL;DR: Clinical and experimental perspectives on the "developmental origins of disease" model are reviewed in the context of new concepts of Evolutionary and life history theory.
Journal ArticleDOI
Insulin Resistance Syndrome in Children
Svetlana Ten,Noel K. Maclaren +1 more
TL;DR: The looming tragedy from growing numbers of individuals affected by obesity/insulin resistance syndrome requires urgent public health approaches directed at their early identification and intervention during childhood, including educating the public on the topic, limiting the consumption of sucrose-containing drinks and foods with high carbohydrate and fat contents, and promoting exercise programs in the authors' nation's homes and schools.
Journal ArticleDOI
Mechanisms involved in the developmental programming of adulthood disease.
TL;DR: How developmental plasticity, although beneficial for short-term survival, can subsequently programme glucose intolerance and insulin resistance in adult life by eliciting changes in key organ structures and the epigenome is highlighted.
References
More filters
Book
Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
Journal ArticleDOI
Fetal and infant growth and impaired glucose tolerance at age 64.
C. N. Hales,David J.P. Barker,Penelope M.S. Clark,Lorna Cox,Caroline H.D. Fall,Clive Osmond,P D Winter +6 more
TL;DR: Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
Journal ArticleDOI
Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales.
David J.P. Barker,Clive Osmond +1 more
TL;DR: Although the rise in ischaemic heart disease in England and Wales has been associated with increasing prosperity, mortality rates are highest in the least affluent areas.
Journal ArticleDOI
Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
TL;DR: It is concluded that Type 2 diabetes and hypertension have a common origin in sub-optimal development in utero, and that syndrome X should perhaps be re-named “the small-baby syndrome”.
Book ChapterDOI
[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios
TL;DR: This chapter discusses the mitochondrial respiratory control and the polarographic measurement of ADP : O ratios and the principle of the oxygen electrode has been summarized, and the design of the vibrating oxygen electrode for use with speetrophotometric studies is illustrated.