Journal ArticleDOI
In situ reactivity of the electrochemically generated nitro radical anion from nitrendipine with glutathione, adenine and uracil
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This article is published in Journal of Electroanalytical Chemistry.The article was published on 1995-01-24. It has received 32 citations till now. The article focuses on the topics: Nitro compound & Uracil.read more
Citations
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Cyclic voltammetric studies on nitro radical anion formation from megazol and some related nitroimidazole derivatives
TL;DR: In this paper, the second-order decay rate constant, k2, and the half-life time, t1/2, for all the nitro radical anions of the studied nitroimidazole derivatives were calculated using the cyclic voltammetry theory for the disproportionation reaction.
Journal ArticleDOI
Reactions of the nitro radical anion of metronidazole in aqueous and mixed solvent: a cyclic voltammetric study
TL;DR: In this paper, cyclic voltammetry was used to investigate the electrochemical reduction of metronidazole at glassy carbon and gold electrodes at different pHs in aqueous solution as well as in mixed solvent.
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Voltammetric studies of aromatic nitro compounds: pH-dependence on decay of the nitro radical anion in mixed media
TL;DR: In this article, a cyclic voltammetric study focused on the coupled chemical reaction of the generated nitro radical anion was carried out in mixed media (water+DMF) at different DMF contents and several pH values on both mercury and carbon electrodes.
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Selective and sensitive furazolidone biosensor based on DNA-modified TiO 2 -reduced graphene oxide
TL;DR: In this article, a new methodology was used to develop a novel and sensitive electrochemical DNA biosensor for determination of furazolidone, which was fabricated from TiO2-reduced graphene oxide (rGO) modified-carbon paste electrode (CPE) decorated with ds-DNA.
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Voltammetric detection of the interactions between RNO2•- and electron acceptors in aqueous medium at highly boron doped diamond electrode (HBDDE)
Murilo Sérgio da Silva Julião,Murilo Sérgio da Silva Julião,Elizabeth Igne Ferreira,Neidenêi Gomes Ferreira,Silvia H.P. Serrano +4 more
TL;DR: In this article, the authors describe the electrochemical behavior of the nitrofurazone (NFZ) in predominantly aqueous medium, in the absence and presence of glutathione (reduced form) (GSH), L-cysteine (Cys) and O 2 using a highly boron doped diamond electrode (HBDDE).
References
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Journal ArticleDOI
Nimodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cerebrovascular disease.
Mark S. Langley,Eugene M. Sorkin +1 more
TL;DR: Preliminary results suggest that nimodipine is potentially useful in other cerebrovascular disorders, particularly ischaemic stroke, and further clinical use should confirm its value as a significant addition to the very limited range of therapeutic choices currently available for patients with this disorder.
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Some reactions and properties of nitro radical-anions important in biology and medicine.
TL;DR: In this article, it was shown that reductive metabolism of nitroaryl compounds, although generally involving nitro radical-anions as obligate intermediates, results in biological damage via reductive metabolites of higher reduction order than the one-electron product.
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Oxygen inhibition of nitroreductase: Electron transfer from nitro radical-anions to oxygen
Peter Wardman,Eric D. Clarke +1 more
TL;DR: The pulse radiolysis technique is used to measure the bimolecular rate constants of this electron-transfer reaction for over 20 nitro compounds, including substituted 2- and 5-nitroimidazoles of interest as antiprotozoal drugs and radiosensitizers, nitrofurans in use as antibacterial agents, and substituted nitrobenzenes previously used as model substrates for nitroreductases.
Some Reactions and Properties of Nitro Radical-Anions Important in Biology and
TL;DR: It seems likely that reductive metabolism of nitroaryl compounds, although generally involving nitro radical-anions as obligate intermediates, results in biological damage via reductive metabolites of higher reduction order than the one-electron product.