In vitro antibacterial effect of Withania somnifera root extract on Escherichia coli.
Mamta Kumari,Renu Gupta +1 more
TLDR
It is concluded that WSR possessed good antibacterial activity, confirming the great potential of bioactive compounds and its rationalizing use in health care.Abstract:
Aim: The aim was to investigate antibacterial activity of Withania somnifera (Ashwagandha), an Indian traditional medicinal plant against Escherichia coli O78, a pathogenic strain. Materials and Methods: Two-fold serial dilutions of 20% aqueous W. somnifera root (WSR) extract were inoculated with E. coli O78 @ 1x10 7 colony forming units grown in nutrient broth. Following inoculation, turbidity optical density was measured by spectrophotometer at 600 nm in all the tubes at 0, 2, 4, 6 and 8 h of incubation at 37°C. Result: The results revealed that the maximum inhibition of bacterial growth was observed at 1:8 dilution of WSR extract. The highest dilution of the extract that showed inhibited growth of the test organism when compared with control was 1:16. Therefore, the minimum inhibitory concentration of aqueous extract of WSR is 1:16. Conclusion: It is concluded that WSR possessed good antibacterial activity, confirming the great potential of bioactive compounds and its rationalizing use in health care.read more
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Comparative Study on the Antibacterial Activity of Phytochemical Flavanones against Methicillin-resistant Staphylococcus aureus.
Tsuchiya,Hironori,Sato,Masaru,Miyazaki,Takashi,Fujiwara,Shuu,Tanigaki,Shingo,Ohyama,Masayoshi,Tanaka,Toshiyuki,Iinuma,Munekazu +15 more
TL;DR: Tetrahydroxyflavanones with these structural characteristics isolated from Sophora exigua and Echinosophora koreensis showed intensive activity to inhibit the growth of all MRSA strains at 3.13-6.25 micrograms/ml.
Journal ArticleDOI
GC-MS Analysed Phyto-Chemicals and Antibacterial Activity of Withania Somnifera (L.) Dunal Extract in the Context of Treatment to Liver Cirrhosis
TL;DR: In this article, a qualitative analysis of different parts of the plant confirms presence of 10 bioactive compounds like Alkaloids, Phenols, Steroids, Terpenoids, etc.
Journal ArticleDOI
Ameliorating effect of Withania somnifera root extract in Escherichia coli-infected broilers.
TL;DR: It is concluded that supplementation of 20% WSR extract @ 20 ml/L of water caused a reduction in the severity, mortality, and recovery period of E. coli infection and enhanced the humoral and cellular immune responses suggesting its protective effect on limiting the pathology of E coli infection in broiler chickens.
Journal ArticleDOI
Withania somnifera dietary supplementation improves lipid profile, intestinal histomorphology in healthy Nile tilapia (Oreochromis niloticus), and modulates cytokines response to Streptococcus infection.
TL;DR: Improved gut health integrity was observed, especially in WS 5% group in terms of increased goblet cell numbers, villous height, the width of lamina propria in all parts of the intestine, and a decrease in the diameter of the intestinal lumen of the distal intestine only.
Journal ArticleDOI
Phytoextracts as Antibacterials: A Review.
Goutam Chandra,Devaleena Mukherjee,Anushree Singha Ray,Soroj Kumar Chatterjee,Indranil Bhattacharjee +4 more
TL;DR: Antimicrobial properties of different plant parts, which act in a low dose, have been organised separately for easy understanding and may help in biological control of bacteria.
References
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Journal ArticleDOI
Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus
Hironori Tsuchiya,Masaru Sato,Takashi Miyazaki,Shuu Fujiwara,Shingo Tanigaki,Masayoshi Ohyama,Toshiyuki Tanaka,Munekazu Iinuma +7 more
TL;DR: In this paper, the minimum inhibitory concentrations (MICs) of phytochemical flavanones to clinical isolates of MRSA were determined by a serial agar dilution method.
Comparative Study on the Antibacterial Activity of Phytochemical Flavanones against Methicillin-resistant Staphylococcus aureus.
Tsuchiya,Hironori,Sato,Masaru,Miyazaki,Takashi,Fujiwara,Shuu,Tanigaki,Shingo,Ohyama,Masayoshi,Tanaka,Toshiyuki,Iinuma,Munekazu +15 more
TL;DR: Tetrahydroxyflavanones with these structural characteristics isolated from Sophora exigua and Echinosophora koreensis showed intensive activity to inhibit the growth of all MRSA strains at 3.13-6.25 micrograms/ml.
Journal ArticleDOI
Studies on the immunomodulatory effects of Ashwagandha.
TL;DR: Treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes, which prevented myelosuppression in mice treated with all three immunosuppressive drugs tested.
Journal ArticleDOI
Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis
TL;DR: Oral administration of the aqueous extracts successfully obliterated salmonella infection in Balb/C mice as revealed by increased survival rate as well as less bacterial load in various vital organs of the treated animals.
Journal ArticleDOI
Methanolic extracts of Withania somnifera leaves, fruits and roots possess antioxidant properties and antibacterial activities.
Nadia Alam,Monzur Hossain,Abdul Mottalib,Siti Amrah Sulaiman,Siew Hua Gan,Ibrahim Khalil,Ibrahim Khalil +6 more
TL;DR: In addition to its antioxidant properties, W. somnifer a exhibited significant antibacterial activities against Gram-negative bacteria, particularly S. typhi.