Journal ArticleDOI
In vitro synthesis of coagulation factors by rat liver slices.
Judith G. Pool,Jean Robinson +1 more
TLDR
Rat liver slices prepared from a perfused liver were incubated in a bicarbonate-buffered salt medium and both tissue and medium were assayed for coagulation factors after various incubation periods.Abstract:
Rat liver slices prepared from a perfused liver were incubated in a bicarbonate-buffered salt medium; both tissue and medium were assayed for coagulation factors after various incubation periods. A...read more
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Journal ArticleDOI
Human hepatoma cells secrete single chain factor X, prothrombin, and antithrombin III.
Daryl S. Fair,Bruce R. Bahnak +1 more
TL;DR: The human hepatoma cell line, Hep G2, was analyzed for the ability to synthesize and secrete several coagulation proteins and the hypothesis of a postsecretion proteolytic cleavage of factor X into the two-chain form is supported.
Journal ArticleDOI
Synthesis of clotting factors by the isolated perfused rat liver.
J P Olson,L L Miller,S B Troup +2 more
Book ChapterDOI
Vitamin K and gamma-carboxyglutamate biosynthesis.
Robert E. Olson,John W. Suttie +1 more
TL;DR: This chapter discusses Vitamin K and γ-Carboxyglutamate Biosynthesis and the intuitive belief that vitamin K should be involved in an electron transport system in expressing its procoagulant activity has been vindicated by recent work.
Journal ArticleDOI
Coagulation defects caused by diphenylhydantoin
TL;DR: A series of experiments was designed to determine whether DPH could induce a deficiency of these factors in vivo, using adult cats, and in vitro, using rat liver slices.
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Synthesis of clotting factors by the isolated perfused rat liver.
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