In Vivo Anti-malarial Tests of Nigella sativa (Black Seed) Different Extracts

TLDR: Both intraperitoneal and oral treatments of the seeds extracts showed suppression activities in all groups of mice with the highest values being noted by the 100 and 200 I¼L kg-1 doses of the ethanol extract and the 100 I¹¬1 dose of the chloroform extract.

Abstract: Nigella sativa (black seed) seeds have been used as a traditional medicine for the treatment of a variety of sicknesses including parasitic diseases. Intraperitoneal and oral administrations of ethanol, chloroform and aqueous seed extracts (50, 100, 200 and 400 I¼L kg-1) of N. sativa, were screened in the 4-day suppressive assays for their anti-malarial properties against Plasmodium berghei in mice. Both intraperitoneal and oral treatments of the seeds extracts showed suppression activities in all groups of mice with the highest values were noted by the 100 and 200 I¼L kg-1 doses of the ethanol extract and by the 100 I¼L kg-1 dose of the chloroform extract which significantly (p