Showing papers in "International Immunopharmacology in 2005"

TL;DR: The published findings provide clear evidence that both the oil and its active ingredients, in particular TQ, possess reproducible anti-oxidant effects through enhancing the oxidant scavenger system, which as a consequence lead to antitoxic effects induced by several insults.

TL;DR: Significant lines of evidence indicate that tocilizumab is able to bind to both sIL-6R and mIL- 6R and to inhibit IL-6 binding to its receptors, leading to the blockade of the IL- 6 signaling through both sil-6r and mil-7R, but not block the signaling of other IL-7 family cytokines.

TL;DR: Results demonstrate a potent suppressive effect of resveratrol on proinflammatory responses of microglia, suggesting a therapeutic potential for this compound in neurodegenerative diseases accompanied by microglial activation.

TL;DR: The antitumor activity of the polysaccharide L-II on mice-transplanted sarcoma 180 was mediated by immunomodulation in inducing T-cells and macrophage-dependent immune system responses.

TL;DR: The relative stability of concentrated versus dilute bromelain solutions to inactivation under physiologically relevant conditions suggests that delivery of bromELain as a concentrated bolus would be the preferred method to maximize its proteolytic activity in vivo.

TL;DR: It is found that polysaccharides between 400 and 5 KDa exhibit the most potent macrophage-activating activity as determined by increased cytokine production, nitric oxide release, expression of surface molecules, and phagocytic activity.

TL;DR: Analysis of the effects of Juniper polysaccharides on murine peritoneal macrophages, cultured J774, and human mononuclear phagocytes suggest that at least part of the beneficial therapeutic effects reported for extracts of juniper cones are due to modulation of monocyte/macrophage immune functions.

TL;DR: The results indicate that A. camphorata inhibits LPS induction of cytokine, iNOS and COX-2 expression by blocking NF-kappaB activation, the first confirmation of the anti-inflammatory potential of this traditionally employed herbal medicine in vitro.

TL;DR: It is demonstrated that APS stimulates macrophages to express iNOS gene through the activation of NF-kappaB/Rel, a polysaccharide isolated from the roots of Astragalus membranaceus, significantly induces nitric oxide production and inducible NO synthase (iNOS) transcription.

TL;DR: Observations suggest that the SBT leaf extract has a significant anti-inflammatory activity and has the potential for the treatment of arthritis.

TL;DR: It seems likely that beta-glucan protects against sepsis-induced oxidative organ injury, as it significantly decreased GSH levels and increased the MDA levels and MPO activity and elevated plasma TNF-alpha levels in septic rats, causing oxidative damage.

TL;DR: It is the theme of HIF being an immunologic sensor that will be explored therein--with special emphasis on the regulatory role of cytokines, the 'biologic response modifiers', or cytokines.

TL;DR: It is suggested that inhibition of PI3K signaling pathway can suppress T-helper type 2 (Th2) cytokine production, eosinophil infiltration, mucus production, and airway hyperresponsiveness in a mouse asthma model and may have therapeutic potential for the treatment of allergic airway inflammation.

TL;DR: Recent studies on the molecular characterization of antigen specific T suppressor cells and tolerogenic APC are presented.

TL;DR: The evaluation of the effects of polysaccharide PSPP on the in vivo immune function of mouse suggests that PSPP improve the immune system and could be regarded as a biological response modifier.

TL;DR: SM can cause long-term effects on the immune system in patients with severe intoxication and the impaired immunity is probably responsible for the increased risk of infections in these patients.

TL;DR: This review focuses on apoptosis and candidate genes linked to the development of oesophageal cancer, which it is hoped may provide diagnostic and therapeutic tools, and potential therapeutic strategies for the management of this carcinoma.

TL;DR: In this paper, B. diffusa hexane, chloroform and ethanol extracts, and two pure compounds Bd-I (eupalitin-3-O-beta-D-galactopyranoside) and Bd -II (Eupalithin) were evaluated in vitro for their effect on T cell mitogen (phytohemagglutinin; PHA) stimulated proliferation of human peripheral blood mononuclear cell (PBMC), mixed lymphocyte culture, lipopolysaccharide (LPS) stimulated nit

TL;DR: In this paper, the effects of RESV (c-RESV), a polyphenol present in red wine, on an array of genes whose expression is controlled by nuclear factor kappa B (NF-nB) and whose transcriptional activation is critical in a number of pathologies (including some cardiovascular diseases).

TL;DR: In vitro studies indicate that D-limonene increased NO production in peritoneal macrophages obtained from tumor-bearing mice, suggesting that in addition to reported properties, D- Limonene modulates the immune response with significant potential for clinical application.

TL;DR: It is demonstrated that RJ prevented the myelosupression induced by the temporal evolution of the tumour and abrogated the splenic haematopoiesis observed in EAT-bearing mice, pointing to RJ as a promising modifier of biological response leading to myeloprotection and antitumour activity.

TL;DR: The results suggest that PA has anti-tumor activity and increases the anti- Tournaisian activity of DOX, and the mechanism might be related partially to immunopotentiating activities through the enhancements of lymphocyte proliferation, NK cell cytotoxicity, CD4+/CD8+ ratio, IL-2 and IFN-gamma productions.

TL;DR: The results suggest that TGP possesses anti-inflammatory effects by modulating the pro-inflammatory mediators production from MLS and phosphorylation of MAPKs from FLS.

TL;DR: It is found that mannose receptor (MR) was the major receptor responsible for oligochitosan uptake and was also engaged in oligoch itosan induced TNF-alpha enhancement and [Ca(2+)](in) flux and may serve as a signaling receptor in oligosamine-induced activation of macrophage function.

TL;DR: The compound K may improve contact dermatitis or psoriasis by the regulation of COX-2 produced by macrophage cells and interferon-gamma and IL-4 induced by Th cells and its metabolite compound K on oxazolone-applied mouse ears.

TL;DR: In this paper, the authors demonstrated that extract of S. miltiorrhiza (ESM) and its major ingredients, Danshensu (DSS) and salvianolic acid B (Sal B), inhibited tumor necrosis factor (TNF-alpha) induced endothelial permeability, whereas the other major ingredient, protocatechualdehyde, was ineffective.

TL;DR: It can be seen that probiotic supplementation modulates the response of the intestinal microflora to the effects of antibiotic therapy.

TL;DR: It is suggested that the imbalance between production of free oxygen radicals and antioxidant defence systems, due to CsA administration, is a mechanism responsible for oxidative stress and it is shown that Mel plays a protective action againstCsA-induced oxidative stress, as supported by biochemical and immunohistochemical results.

TL;DR: Comparisons with triptolide suggested that LLDT-8 had immunosuppressive activities in both cellular and humoral immune responses, and it might be a potential therapeutic agent for immune-related diseases.

TL;DR: Data emphasize the protective value of TQ against development of type I DM via NO inhibitory pathway and significantly inhibited both p44/42 and p38 mitogen-activated protein kinases (MAPKs) which contribute to the transcriptional machinery of inducible nitric oxide synthase and NO production.