Journal ArticleDOI
In vivo study of human skin using pulsed terahertz radiation
TLDR
This work conducts the first ever systematic in vivo study of the response of terahertz radiation to normal skin, and demonstrates that the FDTD model can be applied to biological tissue.Abstract:
Studies in terahertz (THz) imaging have revealed a significant difference between skin cancer (basal cell carcinoma) and healthy tissue. Since water has strong absorptions at THz frequencies and tumours tend to have different water content from normal tissue, a likely contrast mechanism is variation in water content. Thus, we have previously devised a finite difference time-domain (FDTD) model which is able to closely simulate the interaction of THz radiation with water. In this work we investigate the interaction of THz radiation with normal human skin on the forearm and palm of the hand in vivo. We conduct the first ever systematic in vivo study of the response of THz radiation to normal skin. We take in vivo reflection measurements of normal skin on the forearm and palm of the hand of 20 volunteers. We compare individual examples of THz responses with the mean response for the areas of skin under investigation. Using the in vivo data, we demonstrate that the FDTD model can be applied to biological tissue. In particular, we successfully simulate the interaction of THz radiation with the volar forearm. Understanding the interaction of THz radiation with normal skin will form a step towards developing improved imaging algorithms for diagnostic detection of skin cancer and other tissue disorders using THz radiation.read more
Citations
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Journal ArticleDOI
Imaging with terahertz radiation
TL;DR: A comprehensive review of the various techniques used for terahertz image formation can be found in this paper, as well as numerous examples which illustrate the many exciting potential uses for these emerging technologies.
Journal ArticleDOI
Biomedical applications of terahertz technology
E. Pickwell,Vincent P. Wallace +1 more
TL;DR: In this paper, the development of terahertz (THz) technology and a typical system used in biomedical applications is described, considering applications ranging from THz spectroscopy of crystalline drugs to THz imaging of skin cancer.
Journal ArticleDOI
Terahertz pulsed imaging of human breast tumors.
Anthony J. Fitzgerald,Vincent P. Wallace,Mercedes Jimenez-Linan,L Bobrow,Richard J. Pye,Anand D. Purushotham,Donald Dominic Arnone +6 more
TL;DR: The potential of terahertz pulsed imaging to depict both invasive breast carcinoma and ductal carcinoma in situ under controlled conditions is demonstrated and further studies are encouraged to determine the sensitivity and specificity of the technique.
Journal ArticleDOI
Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo
Vincent P. Wallace,Anthony J. Fitzgerald,S. Shankar,Niamh Flanagan,Richard J. Pye,Julian Alexander Cluff,D. D. Arnone +6 more
TL;DR: Terahertz pulsed imaging is a noninvasive imaging technique that utilises this radiaton to excite large amplitude vibrational modes of molecules and probe the weak interactions between them.
Journal ArticleDOI
THz Medical Imaging: in vivo Hydration Sensing
Z. D. Taylor,Rahul Singh,David B. Bennett,Priyamvada Tewari,Colin Kealey,Neha Bajwa,Martin O. Culjat,A. Stojadinovic,Hua Lee,Jean-Pierre Hubschman,Elliott R. Brown,Warren S. Grundfest +11 more
TL;DR: Two promising medical applications of THz imaging are presented: skin burns and cornea and experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.
References
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Journal ArticleDOI
Terahertz pulse imaging in reflection geometry of human skin cancer and skin tissue
Ruth M. Woodward,Bryan E. Cole,Vincent P. Wallace,Richard J. Pye,Donald Dominic Arnone,Edmund H. Linfield,Michael Pepper +6 more
TL;DR: By studying the terahertz pulse shape in the time domain, TPI is able to differentiate between diseased and normal tissue for the study of basal cell carcinoma (BCC) and inflammation and scar tissue.
Journal ArticleDOI
Far-infrared dielectric properties of polar liquids probed by femtosecond terahertz pulse spectroscopy
TL;DR: In this paper, the frequency-dependent optical constants, n(ν) and α(ν), for water, methanol, ethanol, 1-propanol, and liquid ammonia were reported.
Journal ArticleDOI
Investigation of the temperature dependence of dielectric relaxation in liquid water by thz reflection spectroscopy and molecular dynamics simulation
Cecilie Ro,Lars Thrane,Per-Olof Åstrand,Anders Wallqvist,Kurt V. Mikkelsen,So,ren R. Keiding +6 more
TL;DR: In this paper, the real and imaginary part of the dielectric constant of liquid water in the far-infrared region from 0.1 to 2.0 THz in a temperature range from 271.1 K to 366.7 K were obtained with the use of THz time domain reflection spectroscopy.
Journal ArticleDOI
A confocal microwave imaging algorithm for breast cancer detection
Xu Li,Susan C. Hagness +1 more
TL;DR: A computationally efficient and robust image reconstruction algorithm for breast cancer detection using an ultrawideband confocal microwave imaging system and a two-dimensional anatomically realistic MRI-derived FDTD model of the cancerous breast is presented.
Journal ArticleDOI
T-ray tomography.
TL;DR: In this article, the authors demonstrate tomographic T-ray imaging using the timing information present in terahertz (THz) pulses in a reflection geometry, where the time delays of these pulses are used to determine the positions of the discontinuities along the propagation direction.