Journal ArticleDOI
Incidence of severe ovarian hyperstimulation syndrome after GnRH agonist/HMG superovulation for in-vitro fertilization
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TLDR
It is confirmed that the ovulatory HCG dose is the most important factor in inducing this severe complication and luteal supplementation with HCG and/or HCG production during implantation could exacerbate OHSS.Abstract:
In 1673 treatment cycles stimulated with buserelin and HMG, for IVF, GIFT or ZIFT, the severe ovarian hyperstimulation syndrome (OHSS) occurred in 10 cycles (0.6%). Eight patients were hyperandrogenic and showed an increased ovarian response to HMG. After replacement of a maximum of three embryos or zygotes, seven women became pregnant. Three women had a multiple gestation. All patients recovered uneventfully with conservative treatment. Support with progesterone or continuation of the agonist during the luteal phase did not prevent OHSS, confirming that the ovulatory HCG dose is the most important factor in inducing this severe complication. Luteal supplementation with HCG and/or HCG production during implantation could exacerbate OHSS.read more
Citations
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Journal ArticleDOI
Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review
Annick Delvigne,Serge Rozenberg +1 more
TL;DR: Whether it is possible to identify patients at risk of ovarian hyperstimulation syndrome, and which preventive method should be applied when an exaggerated ovarian response occurs, is determined.
Journal ArticleDOI
Ovarian hyperstimulation syndrome in novel reproductive technologies: prevention and treatment.
TL;DR: Although severe and critical OHSS may not be completely avoided, early recognition of high-risk factors, judicious prevention schemes, and treatment strategies should reduce the complication and long-term sequelae of this iatrogenic syndrome.
Journal ArticleDOI
Ovarian hyperstimulation syndrome.
TL;DR: A review of the literature regarding ovarian hyperstimulation syndrome (OHSS) can be found in this article, which is a rare Iatrogenic complication of ovarian stimulation usually occurring during the luteal phase or during the early part of pregnancy.
Journal ArticleDOI
Ovarian hyperstimulation syndrome: classifications and critical analysis of preventive measures
M. A. Aboulghar,R. T. Mansour +1 more
TL;DR: The aim of this review was to summarize previously published classifications for ovarian hyperstimulation syndrome (OHSS), as well as to analyse the available methods for preventing OHSS.
Journal ArticleDOI
The role of vascular endothelial growth factor and interleukins in the pathogenesis of severe ovarian hyperstimulation syndrome
TL;DR: The kinetics of VEGF in the plasma of patients who actually develop severe OHSS are closely correlated with the clinical course of the syndrome and with certain biological characteristics of OHSS and of capillary leakage, such as leukocytosis and increased hematocrit.