Journal ArticleDOI
Inhibition of chrysin on xanthine oxidase activity and its inhibition mechanism
TLDR
Analysis of circular dichroism demonstrated that chrysin induced the conformational change of XO with increases in α-helix and β-sheet and reductions in β-turn and random coil structures, and the interaction was predominately driven by hydrogen bonds and van der Waals forces.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2015-11-01. It has received 54 citations till now. The article focuses on the topics: Chrysin & Xanthine oxidase.read more
Citations
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Journal ArticleDOI
Management of hyperuricemia through dietary polyphenols as a natural medicament: A comprehensive review
Arshad Mehmood,Lei Zhao,Chengtao Wang,Muhammad Nadeem,Ali Raza,Nawazish Ali,Amjad Abbas Shah +6 more
TL;DR: The current comprehensive review figure outs the use of dietary polyphenols as a natural remedy for the management of hyperuricemia and the sources, affiliated pathways, mode of actions and factors affecting their efficiency are deeply discussed in this article.
Journal ArticleDOI
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity
Andrija Smelcerovic,Katarina Tomovic,Žaklina Šmelcerović,Živomir Petronijević,Gordana Kocic,Tihomir Tomašič,Žiga Jakopin,Marko Anderluh +7 more
TL;DR: Derivatives of imidazole, 1,3-thiazole and pyrimidine proved to be more potent than febuxostat while also displaying/possessing favorable predicted physico-chemical, pharmacokinetic and toxicological properties.
Journal ArticleDOI
Natural compounds with xanthine oxidase inhibitory activity: A review.
Arshad Mehmood,Muhammad Ishaq,Lei Zhao,Bushra Safdar,Ashfaq‐ur Rehman,Masooma Munir,Masooma Munir,Ali Raza,Muhammad Nadeem,Waheed Iqbal,Chengtao Wang +10 more
TL;DR: Various bioactive compounds, chemical structures, and structure–activity relationship with responsible key enzyme xanthine oxidase are comprehensively discussed.
Journal ArticleDOI
Bioactive Compounds from Plant-Based Functional Foods: A Promising Choice for the Prevention and Management of Hyperuricemia.
TL;DR: This current and comprehensive review examines the use of bioactive compounds from plant-based functional foods as natural remedies for the management of hyperuricemia and discusses the different bio active compounds and their pharmacological effects.
Journal ArticleDOI
Inhibition mechanism of baicalein and baicalin on xanthine oxidase and their synergistic effect with allopurinol
TL;DR: Baicalein and baicalin, two dietary flavones, were found to inhibit the formation of uric acid and generation of superoxide anion catalysed by XO through interaction with primary amino acid residues located in flavin adenine dinucleotides center of XO.
References
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Journal ArticleDOI
Thermodynamics of protein association reactions: forces contributing to stability
Philip D. Ross,S. Subramanian +1 more
TL;DR: On the basis of the thermochemical behavior of small molecule interactions, it is concluded that the strengthening of hydrogen bonds in the past decade, a complete thermodynamic description of the self-association of many proteins and their interactions is concluded.
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Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
TL;DR: The median-effect principle and its mass-action law based computer software are gaining increased applications in biomedical sciences, from how to effectively evaluate a single compound or entity to how to beneficially use multiple drugs or modalities in combination therapies.
Journal ArticleDOI
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Marilda Mazzali,Jeremy Hughes,Yoon Goo Kim,J. Ashley Jefferson,Duk Hee Kang,Katherine L. Gordon,Hui Y. Lan,Salah D. Kivlighn,Richard J. Johnson +8 more
TL;DR: Mild hyperuricemia causes hypertension and renal injury in the rat via a crystal-independent mechanism, with stimulation of the renin-angiotensin system and inhibition of neuronal NO synthase.
Journal ArticleDOI
Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol
TL;DR: A critical overview of the effects of XO inhibitors in various pathophysiological conditions is presented and the various emerging therapeutic strategies offered by this approach are reviewed.
Journal ArticleDOI
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
TL;DR: The crystal structure of the dimeric bovine milk XDH is presented and the major changes that occur on the proteolytic transformation of XDH to the XO form are described, reflecting the switch of substrate specificity observed for the two forms of this enzyme.