Insulin-i131 metabolism in human subjects: demonstration of insulin binding globulin in the circulation of insulin treated subjects
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This article is published in Journal of Clinical Investigation.The article was published on 1956-02-01 and is currently open access. It has received 812 citations till now. The article focuses on the topics: Insulin & Sex hormone-binding globulin.read more
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Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Carl R Morgan,Arnold Lazarow +1 more
TL;DR: A two antibody system of insulin assay for immunoassay of insulin induces the production of specific nonprecipitating antibodies, both in experimental animals and in humans.
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Immunoassay of endogenous plasma insulin in man
TL;DR: The insulin concentration in plasma has been estimated from the degree of hypoglycemia produced in hypophysectomized, adrenalectomization, alloxan-diabetic rats, and from the increased oxidation of glucose-1-C14 by the rat epididymal fat pad.
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Hormone-fuel interrelationships during fasting.
George F. Cahill,M G Herrera,A P Morgan,J S Soeldner,Jurgen Steinke,P L Levy,G A Reichard,D M Kipnis +7 more
TL;DR: Over 50 years ago, Benedict published his extensive monograph on the metabolism of fasting in man, in which he demonstrated that carbohydrate stores provide a small but significant component of the body's fuel for only the first few days.
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Assay of Plasma Insulin in Human Subjects by Immunological Methods
TL;DR: It has been found that human insulin cross-reacts strongly with insulin-binding antibodies in guinea pigs immunized with crystalline beef insulin, and that guinea pig anti-beef insulin serum has characteristics suitable for the detection and measurement of human insulin at concentrations which exist in the plasma of normal fasting subjects.
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Immunoassay using antigen—enzyme conjugates
TL;DR: Two methods for the assay of human chorionic gonadotrophin (HCG), which employ anti-HCG labelled with horse-radish peroxidase (HRP) are described, analogous to the ‘immunoradiometric’ and the ’sandwich’ radioimmunoassays.
References
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Journal ArticleDOI
Tracer experiments with i131 labeled human serum albumin: distribution and degradation studies
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The principles of bacteriology and immunity
W. W. C. Topley,G. S. Wilson +1 more
TL;DR: T OPley and Wilson's great two-volume work is now in one volume at $12..
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Zone electrophoresis in a starch supporting medium.
Henry G. Kunkel,Robert J. Slater +1 more
TL;DR: Starch proved particularly useful because of its low adsorption of proteins and peptides in aqueous buffers and could be determined quantitatively by phospholipid and cholesterol analyses of the serum fractions.
Journal Article
Quantitative aspects of iodine metabolism in man
TL;DR: The reviewer's opinion, future advances are likely to stem chiefly from the simultaneous use of several techniques in the detailed investigation of small groups of patients, and he would urge that studies with radioactive iodine be supplemented by the determination of stable iodine not only in blood but also in urine.
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Chemical, clinical, and immunological studies on the products of human plasma fractionation. xl. quantitative separation and determination of the protein components in small amounts of normal human plasma
Walter F. Lever,Frank R. N. Gurd,Eero Uroma,Ray K. Brown,Benjamin A. Barnes,Karl Schmid,Ethel L. Schultz +6 more
TL;DR: The present communication describes the adaptation of Method 10 of plasma fractionation developed by Cohn and his associates for the quantitative estimation of certain of the protein and lipoprotein components in small quantities of normal human plasma.