Journal ArticleDOI
Interaction of β-Lactoglobulin with Resveratrol and its Biological Implications
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TLDR
In this article, the interaction of resveratrol with beta-lactoglobulin was investigated using circular dichroism, fluorescence and UV-vis absorbance, and the binding constant for the 2-way interaction was found to be between 10(4 and 10(6) M (-1), as determined by protein or polyphenol fluorescence.About:
This article is published in Biomacromolecules.The article was published on 2008-01-01. It has received 432 citations till now. The article focuses on the topics: Resveratrol.read more
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Milk proteins as vehicles for bioactives
TL;DR: The review highlights the main achievements reported in the last 3 years: harnessing the casein micelle, a natural nanovehicle of nutrients, for delivering hydrophobic bioactives, and discovering unique nanotubes based on enzymatic hydrolysis of α-la.
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Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells.
TL;DR: Fluorescence quenching showed that curcumin molecules quench the intrinsic fluorescence of caseins upon binding, and the utility of CMs as carriers ofCurcumin was evaluated by using in vitro cultured HeLa cells.
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Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds
TL;DR: A number of different approaches can be used to create structured delivery systems based on biopolymers, including molecular complexation, coacervation, thermodynamic incompatibility, molding, and extrusion methods as discussed by the authors.
Journal ArticleDOI
Milk β-lactoglobulin complexes with tea polyphenols.
C.D. Kanakis,Imed Hasni,P. Bourassa,Petros A. Tarantilis,Moschos G. Polissiou,H.A. Tajmir-Riahi +5 more
TL;DR: The β-LG conformation was altered in the presence of polyphenols with an increase in β-sheet and α-helix suggesting protein structural stabilisation, which can be used to explain the mechanism by which the antioxidant activity of tea compounds is affected by the addition of milk.
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Resveratrol, genistein, and curcumin bind bovine serum albumin.
TL;DR: Polyphenol binding altered BSA conformation with a major reduction of alpha-helix and an increase in beta-sheet and turn structures, indicating a partial protein unfolding.
References
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Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
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Dominant forces in protein folding
TL;DR: The present review aims to provide a reassessment of the factors important for folding in light of current knowledge, including contributions to the free energy of folding arising from electrostatics, hydrogen-bonding and van der Waals interactions, intrinsic propensities, and hydrophobic interactions.
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Quenching of fluorescence by oxygen. A probe for structural fluctuations in macromolecules.
TL;DR: In this article, the fluorescence of various fluorophores by molecular oxygen has been studied in aqueous and nonaqueous solutions equilibrated with oxygen pressures up to 100 atm.
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Bovine β-lactoglobulin at 1.8 Å resolution — still an enigmatic lipocalin
Sharon Brownlow,João H. Morais Cabral,Ron Cooper,Darren R. Flower,Stephen J. Yewdall,Igor Polikarpov,Anthony C.T. North,Lindsay Sawyer +7 more
TL;DR: In this article, the structure of β-Lg lattice Z at 3.0 A resolution by multiple isomorphous replacement and have partially refined it (R factor=24.8%).
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Invited Review: β-Lactoglobulin: Binding Properties, Structure, and Function
TL;DR: It is proposed that β -LG, over-expressed in the lactating mammary gland of many, but not all, species, is primarily an important source of amino acids for the offspring of those animals that produce it, but that this function arose by gene duplication from the physiologically essential glycodelin.