Interstitial Lung Disease at High Resolution CT after SARS-CoV-2-Related Acute Respiratory Distress Syndrome According to Pulmonary Segmental Anatomy.
Elisa Baratella,Barbara Ruaro,Cristina Marrocchio,Natalia Starvaggi,Francesco Salton,Fabiola Giudici,Fabiola Giudici,Emilio Quaia,Marco Confalonieri,Maria Assunta Cova +9 more
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In this paper, the authors evaluated high resolution CT (HRCT) findings in SARS-CoV-2-related ARDS survivors treated with prolonged low-dose methylprednisolone after hospital discharge.Abstract:
Background: The purpose of this study was to evaluate High-Resolution CT (HRCT) findings in SARS-CoV-2-related ARDS survivors treated with prolonged low-dose methylprednisolone after hospital discharge. Methods: A total of 44 consecutive patients (M: 32, F: 12, average age: 64), hospitalised in our department from April to September 2020 for SARS-CoV-2-related ARDS, who had a postdischarge CT scan, were enrolled into this retrospective study. We reviewed the electronic medical charts to collect laboratory, clinical, and demographic data. The CT findings were evaluated and classified according to lung segmental distribution. The imaging findings were correlated with spirometry results and included ground glass opacities (GGOs), consolidations, reticulations, bronchiectasis/bronchiolectasis, linear bands, and loss of pulmonary volume. Results: Alterations in the pulmonary parenchyma were observed in 97.7% of patients at HRCT (median time lapse between ARDS diagnosis and HRCT: 2.8 months, range 0.9 to 6.7). The most common findings were linear bands (84%), followed by GGOs (75%), reticulations (34%), bronchiolectasis (32%), consolidations (30%), bronchiectasis (30%) and volume loss (25%). They had a symmetric distribution, and both lower lobes were the most affected areas. Conclusions: A reticular pattern with a posterior distribution was observed 3 months after discharge from severe COVID-19 pneumonia, and this differs from previously described postCOVID-19 fibrotic-like changes. We hypothesized that the systematic use of prolonged low-dose of corticosteroid could be the main reason of this different CT scan appearance.read more
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Different Methods to Improve the Monitoring of Noninvasive Respiratory Support of Patients with Severe Pneumonia/ARDS Due to COVID-19: An Update
Paolo Pelosi,M. Tonelli,Chiara Torregiani,Elisa Baratella,Marco Confalonieri,Denise Battaglini,Alessandro Marchioni,Paola Confalonieri,Enrico Clini,Francesco Salton,Barbara Ruaro +10 more
TL;DR: The needs and available tools for clinical–physiological monitoring that aims at optimizing the ventilatory management of patients affected by acute respiratory distress syndrome due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are reviewed.
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An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)
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The pathogenesis, epidemiology and biomarkers of susceptibility of pulmonary fibrosis in COVID-19 survivors.
Andrea Vianello,Gabriella Guarnieri,Fausto Braccioni,Sara Lococo,Beatrice Molena,Antonella Cecchetto,Chiara Giraudo,Leonardo Bertagna De Marchi,Marco Caminati,Gianenrico Senna +9 more
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Characteristics and Prognostic Factors of Pulmonary Fibrosis After COVID-19 Pneumonia
Elisabetta Cocconcelli,Nicol Bernardinello,Chiara Giraudo,Gioele Castelli,A. Giorgino,Davide Leoni,Simone Petrarulo,Anna Maria Ferrari,Marina Saetta,Anna Maria Cattelan,Paolo Spagnolo,Elisabetta Balestro +11 more
TL;DR: In this population, only twenty percent of patients showed persistent lung abnormalities at 6 months after hospitalization for COVID-19 pneumonia, and the presence of reticulations and consolidation on HRCT at hospital admission predicts the persistence of radiological abnormalities during follow-up.
References
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Evaluation of Correlations between Genetic Variants and High-Resolution Computed Tomography Patterns in Idiopathic Pulmonary Fibrosis.
Elisa Baratella,Barbara Ruaro,Fabiola Giudici,Barbara Wade,Mario Santagiuliana,Francesco Salton,Paola Confalonieri,Michele Simbolo,Aldo Scarpa,Saverio Tollot,Cristina Marrocchio,Maria Assunta Cova,Marco Confalonieri +12 more
TL;DR: In this paper, a prospective observational study aimed at the evaluation of any correlation between genetic variants associated with IPF susceptibility and high-resolution computed tomography (HRCT) patterns.
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Radiological-pathological signatures of patients with COVID-19-related pneumomediastinum: is there a role for the Sonic hedgehog and Wnt5a pathways?
Elisa Baratella,Rossana Bussani,Fabrizio Zanconati,Cristina Marrocchio,Giudici Fabiola,Giudici Fabiola,Luca Braga,Serena Maiocchi,Giorgio Berlot,Maria Concetta Volpe,Edoardo Moro,Paola Confalonieri,Maria Assunta Cova,Marco Confalonieri,Francesco Salton,Barbara Ruaro +15 more
TL;DR: The fibrous hyaline degeneration of tracheal rings seen in this autoptic series is an original observation that has not been previously described in COVID-19 patients as discussed by the authors.
Journal ArticleDOI
Correlation between Potential Risk Factors and Pulmonary Embolism in Sarcoidosis Patients Timely Treated.
Barbara Ruaro,Paola Confalonieri,Mario Santagiuliana,Barbara Wade,Elisa Baratella,Metka Kodric,Maria Berria,Mohamad Jaber,Chiara Torregiani,Cosimo Bruni,Marco Confalonieri,Francesco Salton +11 more
TL;DR: In this article, the presence of antiphospholipid antibody positivity and pulmonary embolism events in sarcoidosis patients was found to be associated with lung cancer.