Showing papers in "Chest in 2013"

TL;DR: Surgical resection remains the primary and preferred approach to the treatment of stage I and II NSCLC, and mediastinal lymph node sampling at the time of curative intent surgical resection can be performed without increased morbidity.

TL;DR: It is demonstrated that PET scanning is more accurate than CT scanning, but tissue biopsy is still required to confirm PET scan findings, and evidence suggests that more complete staging improves patient outcomes.

TL;DR: Recommendations for evaluation and management of individuals with solid pulmonary nodules and those with nonsolid nodules are formulated by using the methods described in the "Methodology for Development of Guidelines for Lung Cancer" in the American College of Chest Physicians Lung Cancer Guidelines, 3rd ed.

TL;DR: The sensitivity of bronchoscopy is high for endobronchial disease and poor for peripheral lesions, while TTNA is associated with a higher rate of pneumothorax compared with bronchoscopic procedures and R-EBUS and EMN are emerging technologies for the diagnosis of peripheral lung cancer.

TL;DR: A careful preoperative physiologic assessment is useful for identifying those patients at increased risk with standard lung cancer resection and for enabling an informed decision by the patient about the appropriate therapeutic approach to treating his or her lung cancer.

TL;DR: A number of studies have shown that there is no single "magic bullet" to combat oxidative stress, but instead a combination therapy, targeting oxidative stress in the various subcellular compartments, may prove to be more effective in COPD.

TL;DR: Almost all lung cancer deaths are caused by cigarette smoking, underscoring the need for ongoing efforts at tobacco control throughout the world.

TL;DR: A validated scheme is derived that can predict poor INR control and aid decision-making by identifying those patients with AF who would do well on VKA, or conversely, those who require additional interventions to achieve acceptable anticoagulation control.

TL;DR: Multimodality therapy is preferable in most subsets of patients with stage III lung cancer, and routine platinum-based adjuvant chemotherapy following complete resection of stage IIIA lung cancer encountered unexpectedly at surgery is supported.

TL;DR: Screening with LDCT of appropriate individuals in the context of a structured process is associated with a significant reduction in the number of lung cancer deaths in the screened population, given the complex interplay of factors inherent in screening.

TL;DR: Systemic MSC administration appears to be safe in patients with moderate to severe COPD and provides a basis for subsequent cell therapy investigations.

TL;DR: In this article, the prognostic value of diastolic pulmonary vascular pressure gradient (DPG) was used to better prognosticate death in patients with out-of-proportion pulmonary hypertension.

TL;DR: Available new evidence suggests that physiotherapy intervention that comprises early progressive mobilization is beneficial for adult patients in the ICU in terms of its positive effect on functional ability and its potential to reduce ICU and hospital length of stay.

TL;DR: Evidence-based guidelines for the staging and treatment of SCLC are provided and the use of PET scanning is likely to improve the accuracy of staging.

TL;DR: The data indicate that ultrasound guidance is associated with decreased risk of pneumothorax with thoracentesis and of bleeding complications with paracentesis, which resulted in measurable increases in hospitalization costs and LOS.

TL;DR: This guideline updates the second edition and addresses patients with particular forms of non-small cell lung cancer that require special considerations, including Pancoast tumors, T4 N0,1 M0 tumors, additional nodules in the same lobe, ipsilateral different lobe, synchronous and metachronous second primary lung cancers, solitary brain and adrenal metastases, and chest wall involvement.

TL;DR: Declines in the age-adjusted prevalence, death rate in men, and hospitalizations for COPD since 1999 suggest progress in the prevention of COPD in the United States.

TL;DR: A systematic review of the published data on lung cancer in China between 1990 and 2011 to analyze the incidence and mortality rates, economic burden, and risk factors of cancer and the effectiveness of interventions found that people in eastern China likely have a higher risk of developing lung cancer than those in western China.

TL;DR: Among patients with chronic HP, when adjusting for a number of potentially influential predictors, including the presence of fibrosis, the inability to identify an IA was independently associated with shortened survival.

TL;DR: Treatment of severe A(H1N1) infection with H-IVIG within 5 days of symptom onset was associated with a lower viral load and reduced mortality.

TL;DR: Airway remodeling is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the necessity for early and specific therapeutic interventions.

TL;DR: Available observational data support the hypothesis that COPD is associated with an increased risk of CVD, and two studies found a relationship between the severity of airflow limitation and CVD risk.

TL;DR: In this article, the authors quantify the incidence of and risk factors for complications in patients undergoing EBUS-TBNA and show that transbronchial lung biopsy (TBBx) was the only risk factor for complications.

TL;DR: Depression and anxiety adversely affect prognosis in COPD, conferring an increased risk of exacerbation and possibly death, and bidirectional associations suggest potential usefulness of screening for these disease combinations to direct timely therapeutic intervention.

TL;DR: CPFE was identified in 8% of patients with IPF and is a distinct, clinical phenotype with potential therapies that remain underutilized and patients with CPFE and IPF have similar mortality.

TL;DR: New information is presented regarding the diagnosis and treatment of patients with ILD secondary to systemic sclerosis, rheumatoid arthritis, dermatomyositis and polymyositis, and Sjögren syndrome and diagnostic criteria for CTD are presented.

TL;DR: This is the fi rst time that the presence of respiratory entrainment in sedated, critically ill adult patients who are mechanically ventilated has been documented and the “reverse-triggered” breaths illustrate a new form of neuromechanical coupling with potentially important clinical consequences.

TL;DR: The potential mechanisms that link COPD to an increased risk of cardiovascular disease are discussed and alternatives to smoking, low socioeconomic class, and a sedentary lifestyle are considered.

TL;DR: In persistent pure GGNs of ≥ 10 mm in diameter, the size and mass of the nodule are determinants of invasive adenocarcinoma, for which surgical resection leads to excellent prognosis.