Journal ArticleDOI
Intravitreal methotrexate for retinoblastoma.
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This article is published in Ophthalmology.The article was published on 2011-08-01. It has received 61 citations till now. The article focuses on the topics: Retinoblastoma.read more
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Journal ArticleDOI
Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications
Francis L. Munier,Marie-Claire Gaillard,Aubin Balmer,Sameh E. Soliman,Gregory Podilsky,Alexandre Moulin,Maja Beck-Popovic +6 more
TL;DR: Despite a possible confounding effect of concomitant chemotherapy prescription using other routes of administration in four of the successfully treated eyes, IViC achieved an unprecedented success rate of tumour control in the presence of vitreous seeding.
Journal ArticleDOI
Profiling safety of intravitreal injections for retinoblastoma using an anti-reflux procedure and sterilisation of the needle track
Francis L. Munier,Sameh E. Soliman,Alexandre Moulin,Marie-Claire Gaillard,Aubin Balmer,Maja Beck-Popovic +5 more
TL;DR: This technique is potentially safe and effective at a low cost and may play a promising role, especially in the treatment of recurrent and/or resistant vitreous disease in retinoblastoma, as an alternative to enucleation and/ or external beam radiotherapy.
Journal ArticleDOI
Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy
Carol L. Shields,Enzo Fulco,Juan D. Arias,Carolina Alarcon,Marco Pellegrini,Pukhraj Rishi,Swathi Kaliki,Carlos Bianciotto,Jerry A. Shields +8 more
TL;DR: The strategy for retinoblastoma management with chemotherapy depends on tumour laterality and stage of disease, and intravitreal chemotherapy is cautiously reserved for recurrent vitreous seeds following other therapies.
Journal ArticleDOI
Intravitreal melphalan for refractory or recurrent vitreous seeding from retinoblastoma.
Fariba Ghassemi,Carol L. Shields +1 more
TL;DR: Intravitreal melphalan for recurrent vitreous seeds from retinoblastoma appears to provide vitreOUS seed control in some patients, and a high dose (50 μg) ofmelphalan is toxic and should be avoided.
Journal ArticleDOI
Intravitreal Melphalan for Persistent or Recurrent Retinoblastoma Vitreous Seeds: Preliminary Results
Carol L. Shields,Fairooz P. Manjandavida,Sruthi Arepalli,Swathi Kaliki,Swathi Kaliki,Sara E. Lally,Jerry A. Shields +6 more
TL;DR: Preliminary short-term results suggest that intravitreal melphalan injection for persistent or recurrent vitreous retinoblastoma seeding can provide tumor control with minimal toxicity and complications.
References
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Journal ArticleDOI
New Guidelines to Evaluate the Response to Treatment in Solid Tumors
Patrick Therasse,Susan G. Arbuck,Elizabeth Eisenhauer,Jantien Wanders,Richard Kaplan,Larry Rubinstein,Jaap Verweij,Martine Van Glabbeke,Allan T. van Oosterom,Michaele C. Christian,S. Gwyther +10 more
TL;DR: A model by which a combined assessment of all existing lesions, characterized by target lesions and nontarget lesions, is used to extrapolate an overall response to treatment is proposed, which is largely validated by the Response Evaluation Criteria in Solid Tumors Group and integrated into the present guidelines.
Journal ArticleDOI
The International Classification of Retinoblastoma predicts chemoreduction success.
Carol L. Shields,Arman Mashayekhi,Angela K. Au,Craig N. Czyz,Ann Leahey,Anna T. Meadows,Jerry A. Shields +6 more
TL;DR: The ICRB can be of assistance in predicting CRD success for retinoblastoma and additional treatment methods are necessary to salvage more group D eyes.
Journal ArticleDOI
Intravitreal methotrexate for treating vitreoretinal lymphoma: 10 years of experience
TL;DR: Vitreoretinal involvement of lymphoma can be controlled effectively and without serious adverse reactions by intravitreal MTX injections, and the consideration of this protocol as a good first-line treatment option for intraocular lymphoma is proposed.
Journal ArticleDOI
Factors predictive of recurrence of retinal tumors, vitreous seeds, and subretinal seeds following chemoreduction for retinoblastoma.
Carol L. Shields,Santosh G Honavar,Santosh G Honavar,Jerry A. Shields,Hakan Demirci,Anna T. Meadows,Thomas Naduvilath +6 more
TL;DR: Chemoreduction combined with focal therapy is effective for selected eyes with retinoblastomas and eyes with subretinal seeds at initial examination are at particular risk for recurrence of retinal tumor and vitreous seeds.
Journal ArticleDOI
Impairments in antifolate transport are common in retinoblastoma tumor samples.
TL;DR: Many patients with retinoblastoma have a genetic predisposition to cancer and external beam radiation therapy and alkylating agent chemotherapy may increase their risk of secondary malignancy.
Related Papers (5)
Intravitreal melphalan for refractory or recurrent vitreous seeding from retinoblastoma.
Fariba Ghassemi,Carol L. Shields +1 more