Iron-Catalyzed Cross-Coupling of Imidoyl Chlorides with Grignard Reagents.

TLDR: A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described, resulting in high yields of 71−96% using 5% iron catalyst in a THF−NMP solvent mixture.

Abstract: A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71−96% using 5% iron catalyst in a THF−NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO2Me) gave excellent yields (89%).

Full text

S39
Iron-Catalyzed Cross-Coupling of Imidoyl
Chlorides with Grignard Reagents
Lars K. Ottesen, Fredrik Ek, and Roger Olsson
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SUPPORTING INFORMATION
Table of Contents
Supporting information file one
General experimental paragraph S3
Experimental details S3-S15
Supporting information file two
13
C NMR S16-S38
Supporting information file three (this file)
1
H NMR S39-S61

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