Isolation of the coenzyme of the galactose phosphate-glucose phosphate transformation.
TLDR
In the initial studies (5) it was found that a thermostable factor was required in the over-all Reactions II and III, which led eventually to the discovery and isolation of glucose diphosphate, which acts as a coenzyme in Reaction III.About:
This article is published in Journal of Biological Chemistry.The article was published on 1950-05-01 and is currently open access. It has received 318 citations till now. The article focuses on the topics: Glucose phosphate & Galactose.read more
Citations
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The function of cytidine coenzymes in the biosynthesis of phospholipides.
TL;DR: The ratio of P32 to Cl4 in the product was closely similar to that of the labeled P-choline, suggesting incorporation of both phosphorus and choline as an intact unit into a phospholipide, presumably lecithin.
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Studies on uridine-diphosphate-glucose.
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The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose
TL;DR: The structure of the enzyme reveals many details of the binding of NAD+ and inhibitors at the active site, and appears to have been guided by the principle of economy in the evolution of binding sites.
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The enzymatic transformation of uridine diphosphate glucose into a galactose derivative
TL;DR: It is concluded that the compound found with treatment of UDPG with an enzyme of S. fragilis is uridine diphosphate galactose, and the bearing of this finding on the mechanism of action of UDPG is discussed.
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The biosynthesis of sucrose.
TL;DR: The discovery was made of an enzyme which catalyzes sucrose synthesis according to the following reaction: UDPG’ and fructose-l-phosphate.
References
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Über die Bestimmung kleiner Pentosemengen, insbesondere in Derivaten der Adenylsäure
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The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography
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Differentiation between ribose-3-phosphate and ribose-5-phosphate by means of the orcinol-pentose reaction.
Harry G. Albaum,W.W. Umbreit +1 more
TL;DR: A new method based on a difference in the rate at which these compounds release their phosphorus in weak acid is described, which may be applied not only to the free ribose phosphates, but also to related compounds which possess them.