Isotype distribution of anticardiolipin antibodies in systemic lupus erythematosus: prospective analysis of a series of 100 patients.
Ricard Cervera,Josep Font,Alfonso López-Soto,F.J. Casals,L Pallarés,Albert Bové,Miguel Ingelmo,Alvaro Urbano-Márquez +7 more
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TLDR
Good specificity and predictive value of the anticardiolipin antibody titre for these clinical manifestations is confirmed, and a significant association was found between aCL and the presence of lupus anticoagulant.Abstract:
A prospective study of IgG and IgM isotypes of anticardiolipin antibodies (aCL) in a series of 100 patients with systemic lupus erythematosus was carried out. To determine the normal range of both isotype titres a group of 100 normal control serum samples was studied and a log-normal distribution of IgG and IgM isotypes was found. The IgG anticardiolipin antibody serum was regarded as positive if a binding index greater than 2.85 (SD 3.77) was detected and a binding index greater than 4.07 (3.90) was defined as positive for IgM anticardiolipin antibody. Twenty four patients were positive for IgG aCL, 20 for IgM aCL, and 36 for IgG or IgM aCL, or both. IgG aCL were found to have a significant association with thrombosis and thrombocytopenia, and IgM aCL with haemolytic anaemia and neutropenia. Specificity and predictive value for these clinical manifestations increased at moderate and high anticardiolipin antibody titres. In addition, a significant association was found between aCL and the presence of lupus anticoagulant. Identification of these differences in the anticardiolipin antibody isotype associations may improve the clinical usefulness of these tests, and this study confirms the good specificity and predictive value of the anticardiolipin antibody titre for these clinical manifestations.read more
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Antiphospholipid syndrome: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients
Ricard Cervera,J.C. Piette,Josep Font,Munther A. Khamashta,Yehuda Shoenfeld,María Teresa Camps,Søren Jacobsen,Gabriella Lakos,Angela Tincani,Irene Kontopoulou-Griva,Mauro Galeazzi,Pier Luigi Meroni,Ronald H. W. M. Derksen,Philip G. de Groot,Erika Gromnica-Ihle,Marta Baleva,Marta Mosca,Stefano Bombardieri,Frédéric Houssiau,Jean-Christophe Gris,Isabelle Quéré,Eric Hachulla,Carlos Vasconcelos,B. Roch,Antonio Fernández-Nebro,Marie Claire Boffa,Graham R. V. Hughes,Miguel Ingelmo +27 more
TL;DR: An association with SLE, the patient's sex, and the patient’s age at disease onset can modify the disease expression and define specific subsets of APS.
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Antiphospholipid Thrombosis: Clinical Course after the First Thrombotic Event in 70 Patients
TL;DR: Recurrent thrombosis is a potentially serious problem for patients with lupus anticoagulant or anticardiolipin antibodies or both and intermediate- to high-intensity warfarin therapy or aspirin therapy may confer better antithrombotic protection.
Journal ArticleDOI
Epidemiology of the Antiphospholipid Antibody Syndrome
TL;DR: The frequency of complications of antiphospholipid antibodies (thrombosis, pregnancy morbidity) in the literature and in the Hopkins Lupus Cohort is summarized.
Journal ArticleDOI
1982 revised criteria for classification of systemic lupus erythematosus--ten years later.
Josep Font,Ricard Cervera +1 more
TL;DR: Criteria were expressly designed for the purpose of patient classification in reports relating to clinical, serological, or pathogenetic studies of SLE, they are frequently and wrongly used as a diagnostic tool.
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Association of antibodies against phospholipids with heart valve disease in systemic lupus erythematosus.
Munther A. Khamashta,Ricard Cervera,Ronald A. Asherson,Graham R. V. Hughes,D.J. Coltart,Josep Font,Miguel Ingelmo,C. Paré,Antonio Gil,J.J. Vázquez,José M. Oliver +10 more
TL;DR: Valvular heart disease, particularly affecting the mitral valve, is common in patients with SLE, and the presence of antibodies against phospholipids is associated with a higher prevalence of valvular abnormalities in these patients.
References
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Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus
E. N. Harris,Boey Ml,C G Mackworth-Young,A. E. Gharavi,B. M. Patel,S. Loizou,Graham R. V. Hughes +6 more
TL;DR: A new solid-phase radioimmunoassay for the detection of anticardiolipin antibodies is 200-400 times more sensitive than the precipitation method used in the Venereal Disease Reference Laboratory test and appears to have predictive value for thrombosis in SLE and related disorders.
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Anticardiolipin antibodies: isotype distribution and phospholipid specificity.
TL;DR: Quantitative isotype specific enzyme linked immunosorbent assay (ELISA) was used to determine the distribution of immunoglobulin isotypes and phospholipid specificities of anticardiolipin (anti-CL) antibodies in 40 patients with one or more of the following 'antiphospholIPid antibody associated clinical complications'--namely, thrombosis, fetal loss,Thrombocytopenia.
Journal Article
Measurement of anti-cardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results.
TL;DR: A strong correlation was found between the ELISA and radioimmunoassay methods for measuring ACA of both IgG and IgM classes and should make it a useful and reliable method for clinical and experimental monitoring of patients with SLE and associated autoimmune disorders.
Journal ArticleDOI
Thrombosis, Recurrent Fetal Loss, and Thrombocytopenia: Predictive Value of the Anticardiolipin Antibody Test
E. Nigel Harris,John K. H. Chan,Ronald A. Asherson,Victor R. Aber,Azzudin E. Gharavi,Graham R. V. Hughes +5 more
TL;DR: It is suggested that the IgG ACA test may be a useful predictor forThrombosis, recurrent fetal loss, and thrombocytopenia in patients with autoimmune disorders.