Journal ArticleDOI
Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus
E. N. Harris,Boey Ml,C G Mackworth-Young,A. E. Gharavi,B. M. Patel,S. Loizou,Graham R. V. Hughes +6 more
TLDR
A new solid-phase radioimmunoassay for the detection of anticardiolipin antibodies is 200-400 times more sensitive than the precipitation method used in the Venereal Disease Reference Laboratory test and appears to have predictive value for thrombosis in SLE and related disorders.About:
This article is published in The Lancet.The article was published on 1983-11-26. It has received 1324 citations till now. The article focuses on the topics: Lupus anticoagulant & Anti-cardiolipin antibodies.read more
Citations
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Journal ArticleDOI
Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.
TL;DR: In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries, and the presence and clinical associations or antiphospholipid antibodies in patients with SLE was suggested.
Journal ArticleDOI
International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop.
Wendell A. Wilson,Azzudin E. Gharavi,Takao Koike,Michael D. Lockshin,D. Ware Branch,J.C. Piette,Robin L. Brey,Ronald H. W. M. Derksen,E. Nigel Harris,Graham R. V. Hughes,Douglas A. Triplett,Munther A. Khamashta +11 more
Journal ArticleDOI
The antiphospholipid syndrome.
TL;DR: The broad spectrum of renal diseases that have been observed in association with this syndrome are discussed, and the impact that APS may have on pre-existing renal disease as well as current recommendations for treatment of APS are discussed.
Journal ArticleDOI
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor
Monica Galli,Tiziano Barbui,Paul Comfurius,C. Maassen,H.C. Hemker,Robert F. A. Zwaal,Edouard M. Bevers,M. De Baets,P.J.C. van Breda-Vriesman +8 more
TL;DR: The binding of affinity-purified anticardiolipin antibodies (ACA) to liposomes that contained cardiolip in or phosphatidylserine was investigated and aca-cofactor, a single chain polypeptide with an apparent molecular weight of 50 kD (non-reduced), increases to 70 kD upon reduction, and its properties closely resemble those of beta 2-glycoprotein I (apolipoprotein H).
Journal ArticleDOI
The antiphospholipid syndrome. Diagnosis, management, and pathogenesis.
TL;DR: Clinically, major characteristics of the disorder have been defined, but the course of the disease and its relationship to other disorders, such as systemic lupus erythematosus (SLE), need to be defined.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
The Partial Thromboplastin Time with Kaolin: A Simple Screening Test for First Stage Plasma Clotting Factor Deficiencies
TL;DR: Waaler has demonstrated that long times with normal plasma may be caused by inadequate contact activation of the test plasma when, and it is shown that the partial thromboplastin time technic is not widely used in clinical laboratories.
Journal ArticleDOI
Arterial thrombosis, intrauterine death and "lupus" anticoagulant: detection of immunoglobulin interfering with prostacyclin formation
L O Carreras,S. J. Machin,Rene Deman,Ghislain Defreyn,Jos Vermylen,Bernard Spitz,André Van Assche +6 more
TL;DR: In a 31-year-old woman with a history of recurrent arterial thrombosis, a "lupus" anticoagulant was identified and an antibody in this patient may interfere with the production or release of PGI2 by the vessel wall, possibly by interfering with the availability of arachidonic acid.
Journal ArticleDOI
Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant.
TL;DR: The lupus anticoagulant appears to be a useful marker for a subset of patients with systemic l upus erythematosus at risk for the development of thromboembolic complications.
Journal ArticleDOI
Thrombosis in Patients with the Lupus Anticoagulant
TL;DR: It is suggested that patients with the lupus anticoagulant may be at increased risk of thrombosis.