Journal ArticleDOI
Kallikrein in the male reproductive system.
TLDR
An improvement of seminalysis was observed following long term administration of 600 U/day of hog kallikrein in the male infertile patients and the results of column chromatography suggested that kallIKrein combined with the other substances to form a high molecular compound in the semen.Abstract:
Male genital organs were stained by the peroxidase-antiperoxidase (PAP) method to know the location of kallikrein. Sertoli cells of the testis, epithelial cells that existed from the body to the tail of the epididymis, and glandular cells of the prostate were specifically stained showing that kallikrein was produced in these cells. The concentration of kallikrein in the semen specimens mainly from patients with male sterility and from those who were subjected to vasoligation and in the prostatic fluid specimens from normal controls were measured by radioimmunoassay (RIA). The results of column chro-matography suggested that kallikrein combined with the other substances to form a high molecular compound in the semen. The kallikrein level in the semen from the normal control was 40.4 ± 21.3 ng/ml, which was more than 10 times that in the blood. The value tended to increase with the decrease of the number of spermatozoa. The kailikrein level in the semen from patients with azoospermia was 74.2 ± 23.5 ng/ml, ...read more
Citations
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Journal ArticleDOI
Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis.
TL;DR: It is reported here that hsf2−/− mice exhibit multiple phenotypes, including an increased prenatal lethality occurring between mid‐gestation to birth, with fetal death probably due to central nervous system defects including collapse of the lateral ventricles and ventricular hemorrhages, and suggest that hSF2 has a major function in controlling expression of genes important for embryonic development and maintenance of sperm production.
Journal ArticleDOI
Novel pathways associated with bypassing cellular senescence in human prostate epithelial cells
Steven R. Schwarze,Samuel E. DePrimo,Lisa M. Grabert,Vivian X. Fu,James D. Brooks,David F. Jarrard +5 more
TL;DR: Three genes, the chemokine BRAK,DOC1, and a member of the insulin-like growth factor axis,IGFBP-3, may function in novel pathways that regulate senescence and are inactivated during immortalization, which may be critical not only in allowing cells to bypasssenescence in vitro but in the progression of prostate cancer in vivo.
Journal ArticleDOI
Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence
Armin J. Becker,Stefan Ückert,Christian Georg Stief,Michael C. Truss,S. Machtens,Friedemann Scheller,Wolfram H. Knapp,Uwe Hartmann,Udo Jonas +8 more
TL;DR: Results suggest that penile cavernous smooth muscle tone is partially balanced by kinin-induced relaxation and AN II-induced contraction, and there might be a rationale for the use of angiotensin-converting enzyme inhibitors in the treatment of erectile dysfunction associated with arterial hypertension.
Book ChapterDOI
The Molecular Biology of the Kallikreins and their Roles in Inflammation
TL;DR: A review of the molecular biology of the tissue kallikrein (KLK) gene family can be found in this article, focusing on the differences in gene structure and organization between the plasma and tissue KLK genes and the latter family of genes.
References
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Journal ArticleDOI
Cellular origin of urinary kallikreins.
TL;DR: Specific fluorescence for kallikrein was localized to 8.
Journal ArticleDOI
Kallikrein localization in rodent salivary glands and kidney with the immunoglobulin-enzyme bridge technique.
TL;DR: Phenylephrine administration resulted in loss of immunoreactive granules from the granular convoluted tubule cells of male mouse submandibular gland, paralleled by a biochemically demonstrable decrease in kallikrein-like tosylarginine methyl ester (TAME) esterase activity.
Journal ArticleDOI
Site of kininogenase secretion in the dog nephron.
TL;DR: It is concluded that kininogenases are secreted into the urine at the level of the distal nephron by either the tubule itself or by a specialized structure located at this part of the nephrons, such as the macula densa.
Journal ArticleDOI
Recent progress in pharmacological therapy of male subfertility--a review.
TL;DR: Pharmakologische Therapie der Subfertilität des Mannes ist eine wirklich-physiologisch-konstruktivität beziehungsweise eine ganze politische Beziehungen zur Verfertigung von Krankheiten und Wirklichkeit.
Renal kallikrein: its localization and possible role in renal function.
Carretero Oa,Scicli Ag +1 more
TL;DR: It was concluded that kallikrein is secreted into the urine at the level of the distal tubule by either the tubule itself or by a structure related to this part of the nephron.