Journal ArticleDOI
L-tryptophan and 5-hydroxytryptophan in the treatment of depression. A review.
G. D'Elia,L. Hansonan,H. Raotma +2 more
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TLDR
Trial performed do not provide evidence for an antidepressant effect of 5‐HTP, but there is support for the use of this drug in clinical practice.Abstract:
Trials performed do not provide evidence for an antidepressant effect of 5-HTP. L-TP, without interacting pharmaca, does not appear to be a well-documented antidepressant. The only convincing evidence for L-TP as an antidepressant is that L-TP enhances the effect of MAOI.read more
Citations
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Mianserin: A Review of its Pharmacological Properties and Therapeutic Efficacy in Depressive Illness
TL;DR: Experimental studies in animals indicate that mianserin is less liable to cause cardiotoxicity than the tricyclic drugs, amitriptyline, imipramine or clomipramines, or the modified tricyClic drug maprotiline.
Journal ArticleDOI
L-kynurenine: its synthesis and possible regulatory function in brain.
Gál Em,A.D. Sherman +1 more
TL;DR: Excessively high doses of tryptophan may actually decrease the production of cerebral serotonin and 5-hydroxyindoleacetic acid.
Journal ArticleDOI
Increased serum glutamate in depressed patients.
TL;DR: It was revealed that the elevated serum glutamate concentration in the endogenous and neurotic depressive patients was probably caused by medication, and the effect of antidepressants upon the serum glutamate in the affective disorders was discussed.
Journal ArticleDOI
Plasma Tryptophan and Five Other Amino Acids in Depressed and Normal Subjects
TL;DR: This work has shown that when depression was most severe, depressed patients had lower TRP/5aa ratios and total TRP levels and higher PHE and TYR levels and after patients' conditions improved, these differences disappeared.
References
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Journal Article
Evidence for the existence of monoamine-containing neurons in the central nervous system. i. demonstration of monoamines in the cell bodies of brain stem neurons.
Dahlstroem A,Fuxe K +1 more
Journal ArticleDOI
Dynamic response of chest wall and lung injuries in rabbits exposed to air shock waves of short duration.
Carl-Johan Clemedson,Joensson A +1 more
TL;DR: The chest walls of rabbits exposed to steep-fronted air shock waves of short duration produced by 50 g spherical charges of TNT were recorded by means of a mechano-electric motion transducer to study the correlation between the deformations of the chest and the damage inflicted to the underlying organs, especially the lungs.
Journal ArticleDOI
The effects of precursor loading in the cerebral metabolism of 5‐hydroxyindoles
A. T. B. Moir,D. Eccleston +1 more
TL;DR: It is concluded that there are regional differences within brain in storage, turnover or metabolic fate of 5‐HT, and that turnover through the system is normally controlled by intracerebral tryptophan 5‐hydroxylase in both rats and dogs although there are differences between the species in the cerebral metabolism of5‐HT.
Journal ArticleDOI
Potentiation of the antidepressive effect of a monoamine-oxidase inhibitor by tryptophan
Journal ArticleDOI
The efficacy of antidepressant drugs. A review of research (1958-1972).
Jeffery B. Morris,Aaron T. Beck +1 more
TL;DR: An extensive review of published research on the efficacy of antidepressant medications is presented, which includes 146 double-blind studies on medications actively promoted in the United States as antidepressants during 1972 and lithium carbonate was not conclusively shown to be an effective antidepressant.