Left ventricular diastolic dysfunction: Early diastolic relaxation and late diastolic compliance
TLDR
Because of the ease with which Doppler echocardiographic measurements of transmitral flow during early diastole (E velocity) and atrial systole (A velocity) can be used to calculate the E/A ratio as a single index of diastolic performance, this method has become most popular for clinical detection of left ventricular diastolics dysfunction.About:
This article is published in Journal of the American College of Cardiology.The article was published on 1989-02-01 and is currently open access. It has received 57 citations till now. The article focuses on the topics: Diastole & Doppler echocardiography.read more
Citations
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Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites
M. Pozzi,Stefano Carugo,G Boari,V Pecci,S. De Ceglia,S Maggiolini,G.B. Bolla,Luigi Roffi,Monica Failla,Guido Grassi,Cristina Giannattasio,Giuseppe Mancia +11 more
TL;DR: It is speculated that neurohumoral overactivity, known to stimulate cardiac tissue growth, may challenge the heart, promoting fibrosis and exerting a further hindrance to ventricular relaxation in patients with cirrhosis experiencing episodes of ascites.
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The Role of Hypertension in the Pathogenesis of Heart Failure: A Clinical Mechanistic Overview
TL;DR: The observed structural and functional changes associated with hypertension evolve over decades and are preventable with effective antihypertensive treatment and emphasize the importance of early diagnosis and effective treatment of hypertension to prevent cardiac complications.
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Diabetic and hypertensive heart disease.
Ehud Grossman,Franz H. Messerli +1 more
TL;DR: The presence of diabetes mellitus reduces survival after myocardial infarction and is associated with an increased rate of sudden death caused by ventricular arrhythmia in patients with diabetes.
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Congestive heart failure with normal left ventricular systolic function. Clinical approaches to the diagnosis and treatment of diastolic heart failure.
TL;DR: The syndrome of congestive heart failure with preserved left ventricular systolic function is common in clinical practice and advancing age, often in association with hypertension, coronary artery disease, tachycardia, and atrial fibrillation, is commonly associated with the disorder.
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Determinants of the Doppler flow velocity profile through the mitral valve of the human fetus.
TL;DR: In this paper, the authors identify which of the two variables, E or A, is the contributory factor to the increased E/A ratio and assess the relative influence of gestational age, heart rate, and stroke volume on the flow velocity profile through the fetal mitral valve.
References
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Relation of transmitral flow velocity patterns to left ventricular diastolic function: New insights from a combined hemodynamic and Doppler echocardiographic study
TL;DR: Mitral flow velocity recordings have clinical potential in assessing left ventricular diastolic function that merits further investigation, despite the indirect method of estimation and certain limitations.
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Hemodynamic determinants of the time-course of fall in canine left ventricular pressure.
TL;DR: The present studies show that the time-course of isovolumic pressure fall subsequent to maximum negative dP/dt is exponential, independent of systolic stress and end-systolic fiber length, and minimally dependent on heart rate.
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Left ventricular filling dynamics: influence of left ventricular relaxation and left atrial pressure.
Y. Ishida,Jay S. Meisner,K. Tsujioka,J. I. Gallo,C Yoran,Robert W.M. Frater,Edward L. Yellin +6 more
TL;DR: PRFR is determined by both the left atrial pressure and the left ventricular relaxation rate and should be used with caution as an index ofleft ventricular diastolic function.
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Hypertensive hypertrophic cardiomyopathy of the elderly.
TL;DR: Using echocardiography, a syndrome that included severe concentric cardiac hypertrophy, a small left ventricular cavity, and supernormal indexes of systolic function without concurrent medical illness or ischemic heart disease is identified.
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Factors which affect the diastolic pressure-volume curve.
TL;DR: The observation that the pressure-volume curve changes with disease motivated considerable effort to compute a clinical index of cardiac stiffness to quantify the extent and severity of ischemia.