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Leucocyte Typing IV. White Cell Differentiation Antigens
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This article is published in Immunology.The article was published on 1991-01-01 and is currently open access. It has received 61 citations till now. The article focuses on the topics: Typing.read more
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A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.
TL;DR: A novel mAb (CBRM1/5) that binds to an activation-specific neoepitope on a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorobol esters but does not recognize Mac- 1 on resting myeloid cells is described.
Journal ArticleDOI
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).
TL;DR: A direct interaction between Mac- 1 and heparan sulfate glycans is demonstrated and it is suggested that either N- or O-sulfation is sufficient for heparin to bind efficiently to Mac-1.
Journal ArticleDOI
Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.
Manuel López-Cabrera,Ana G. Santis,Elena Fernández-Ruiz,R Blacher,F Esch,Paloma Sánchez-Mateos,Francisco Sánchez-Madrid +6 more
TL;DR: Protein sequence homology search revealed that CD69 is a new member of the Ca(2+)-dependent (C-type) lectin superfamily of type II transmembrane receptors, which includes the human NKG2, the rat NKR-P1, and the mouse NKR -P1 families of NK cell-specific genes.
Journal ArticleDOI
Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.
TL;DR: The presence of CD45RO and the lack ofCD45R on human cells capable of initiating hemopoiesis in the long-term marrow culture system correspond to the reported lack of CD 45R on transplantable hemopOietic stem cells in rodents and may be a useful addition to strategies for human stem cell purification, or for purging CD45R+ leukemic cells.
Journal ArticleDOI
Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein.
TL;DR: Investigation of the effect of transfection of CD14 into 70Z/3 cells on LPS responsiveness provides evidence to support the concept that the LPS receptor in cells that constitutively express CD14 may be a multiprotein complex containing CD14 and membrane protein common to a diverse group of LPS- responsive cells.
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Journal ArticleDOI
A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.
TL;DR: A novel mAb (CBRM1/5) that binds to an activation-specific neoepitope on a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorobol esters but does not recognize Mac- 1 on resting myeloid cells is described.
Journal ArticleDOI
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).
TL;DR: A direct interaction between Mac- 1 and heparan sulfate glycans is demonstrated and it is suggested that either N- or O-sulfation is sufficient for heparin to bind efficiently to Mac-1.
Journal ArticleDOI
Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.
Manuel López-Cabrera,Ana G. Santis,Elena Fernández-Ruiz,R Blacher,F Esch,Paloma Sánchez-Mateos,Francisco Sánchez-Madrid +6 more
TL;DR: Protein sequence homology search revealed that CD69 is a new member of the Ca(2+)-dependent (C-type) lectin superfamily of type II transmembrane receptors, which includes the human NKG2, the rat NKR-P1, and the mouse NKR -P1 families of NK cell-specific genes.
Journal ArticleDOI
Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.
TL;DR: The presence of CD45RO and the lack ofCD45R on human cells capable of initiating hemopoiesis in the long-term marrow culture system correspond to the reported lack of CD 45R on transplantable hemopOietic stem cells in rodents and may be a useful addition to strategies for human stem cell purification, or for purging CD45R+ leukemic cells.
Journal ArticleDOI
Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein.
TL;DR: Investigation of the effect of transfection of CD14 into 70Z/3 cells on LPS responsiveness provides evidence to support the concept that the LPS receptor in cells that constitutively express CD14 may be a multiprotein complex containing CD14 and membrane protein common to a diverse group of LPS- responsive cells.