Journal ArticleDOI
Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease.
Frédéric Calon,Ali H. Rajput,Oleh Hornykiewicz,Oleh Hornykiewicz,Paul J. Bédard,Thérèse Di Paolo +5 more
TLDR
Findings suggest that glutamate receptor supersensitivity in the putamen plays a role in the development of motor complications following long-term levodopa therapy in Parkinson's disease patients.About:
This article is published in Neurobiology of Disease.The article was published on 2003-12-01. It has received 208 citations till now. The article focuses on the topics: Dopamine receptor D1 & Caudate nucleus.read more
Citations
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Journal ArticleDOI
Molecular mechanisms of L-DOPA-induced dyskinesia
TL;DR: A reinterpretation of recent data suggests that priming for dyskinesia results from nigral denervation and the loss of striatal dopamine input, which alters glutamatergic synaptic connectivity in the striatum.
Journal ArticleDOI
Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
TL;DR: Recent research has improved both the clinical and neuropathological diagnostic criteria of PD and provided insights into the development and staging of αSyn and Lewy pathologies and has been useful in understanding the pathogenesis of PD.
Journal ArticleDOI
Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders
Valerie Voon,Pierre-Olivier Fernagut,Jeff Wickens,Christelle Baunez,Manuel Rodriguez,Manuel Rodriguez,Nancy Pavón,Jorge L. Juncos,Jose A. Obeso,Jose A. Obeso,Erwan Bezard +10 more
TL;DR: Clinical features, overlapping molecular mechanisms, and a specific cognitive mechanism of habit learning that might underlie these behaviours are reviewed and integrated with the emerging view of the basal ganglia as a distributive system involved in the selection and facilitation of movements, acts, and emotions.
Book ChapterDOI
Molecular mechanisms of l-DOPA-induced dyskinesia.
Gilberto Fisone,Erwan Bezard +1 more
TL;DR: The molecular mechanisms implicated in the emergence and manifestation of l-DOPA-induced dyskinesia (LID) are described, with particular emphasis given to the role played in this condition by abnormalities in signal transduction at the level of the medium spiny neurons of the striatum.
Journal ArticleDOI
The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease
TL;DR: It is proposed that to optimally alleviate this motor complication of Parkinson’s disease, it may be necessary to develop combined treatment approaches that will target simultaneously more than one neurotransmitter system.
References
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Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
Journal ArticleDOI
Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
André Parent,Lili-Naz Hazrati +1 more
TL;DR: The basal ganglia circuitry is designed so as to modulate in a precise manner the neuronal activity of several brain functional systems, which are involved in the direct control of different aspects of psychomotor behavior.
Journal ArticleDOI
Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidum in basal ganglia circuitry.
André Parent,Lili-Naz Hazrati +1 more
TL;DR: The GPe stands as an additional integrative station, together with the striatum and the internal pallidum and substantia nigra pars reticulata, along the main steam of information processing within the basal ganglia circuitry, which forces the view of the functional identity of the subthalamic nucleus and the GPe to be modified.
Journal ArticleDOI
Microcircuitry of the direct and indirect pathways of the basal ganglia.
TL;DR: The findings summarized in this commentary confirm and elaborate the models of the direct and indirect pathways of information flow through the basal ganglia and provide a morphological framework for future studies.
Journal ArticleDOI
Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA
TL;DR: The complete nucleotide sequence of a human beta actin cDNA is reported, and conservation of sequences suggests that strong selective pressures operate on non-translated segments of Beta actin mRNA.