Jorge L. Juncos

TL;DR: Coenzyme Q10 appears to slow the progressive deterioration of function in PD, but these results need to be confirmed in a larger study.

TL;DR: Two independent variants in MAPT affecting risk for PSP are confirmed, one of which influences MAPT brain expression and the genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface and for a myelin structural component.

TL;DR: Mitochondrial DNA variants associated with Alzheimer disease (AD) and Parkinson disease (PD) were sought by restriction endonuclease analysis in a cohort of 71 late-onset Caucasian patients and one patient harbored an additional novel 12S rRNA 5-nucleotide insertion at np 956-965.

TL;DR: It is concluded that Parkinson's disease is a systemic disorder of Oxphos, probably of a complex genetic etiology, and premature cell death in the nigrostriatal dopamine pathway could be due to energetic impairment and accentuated free radical generation caused by anOxphos defect.

TL;DR: Clinical features, overlapping molecular mechanisms, and a specific cognitive mechanism of habit learning that might underlie these behaviours are reviewed and integrated with the emerging view of the basal ganglia as a distributive system involved in the selection and facilitation of movements, acts, and emotions.